Scientists at the MRC National Institute for Medical Research
(now part of the Francis Crick Institute) have
identified and characterized an antibody that targets all of the
strains of a type of influenza that is dangerous to humans
(influenza-A), including swine flu, bird flu and Spanish flu.
This work, published online ahead of print inScience, raises the potential for emergency treatment
and of developing pan-influenza vaccines designed to produce such
an antibody, against the viral haemagglutinin - which is found on
the surface of the virus and attaches it to the cell which is being
infected.
The work led by Steve Gamblin and John Skehel at NIMR, published
in Science, was carried out in collaboration with a team from the
Institute for Research in Biomedicine in Switzerland. It follows
earlier work from NIMR scientists which found that some strains of
human influenza viruses carry a mutation in the viral neuraminidase
(an enzyme on the surface of the virus) that makes them resistant
to the anti-viral drug Tamiflu, but not Relenza.
Because of the threat and the cost of severe influenza,
emphasized in the UK during the 2009 pandemic, there has been
strong interest in developing drugs that would block all influenza
virus infections and could, therefore, be stockpiled for use in
emergencies. Antibodies that neutralize virus infections could be
ideal candidates for such stockpiles.
Steve Gamblin explained: "A number of antibodies have been
reported to be effective in blocking infection by one or the other
group of influenza A viruses, but this paper describes a human
antibody that reacts with all influenza A viruses by binding to one
of their membrane glycoproteins, the haemagglutinin.
"Characterization of the antibody including by use of X-ray
crystallography of antibody-haemagglutinin complexes, shows how,
unlike previously reported antibodies, the new antibody is able to
bind to both groups of viruses despite their
characteristically different structural features."
Scientists from the MRC National Institute for Medical Research
and Cancer Research UK's London Research Institute will work
together with scientists from UCL (University College London) in
The Francis Crick Institute. The Institute will draw on the
strengths of its founder organisations to conduct groundbreaking
research into the biological mechanisms controlling cell, tissue
and body function.
Original article
A neutralizing antibody selected from plasma cells that binds to
group 1 and group 2 influenza A hemagglutinins
Davide Corti, Jarrod Voss, Steven J.
Gamblin, Giosiana Codoni, Annalisa Macagno, David
Jarrossay, Sebastien G. Vachieri, Debora
Pinna, Andrea Minola, Fabrizia Vanzetta, Chiara
Silacci, Blanca M. Fernandez-Rodriguez, Gloria
Agatic, Siro Bianchi, Isabella
Giacchetto-Sasselli, Lesley Calder, Federica
Sallusto, Patrick Collins, Lesley F. Haire, Nigel
Temperton, Johannes P. M. Langedijk, John J.
Skehel, Antonio Lanzavecchia.
Science epub ahead of print.