Scientists have discovered that the same specialised immune
cells that patrol the body and spot infections also trigger the
expansion of immune organs called lymph nodes.
The immune system defends the body from infections and can also
spot and destroy cancer cells. Lymph nodes are at the heart of this
response, but until now it has never been explained how they expand
during disease.
The researchers - at Cancer Research UK's London Research
Institute (LRI; now part of the Francis Crick
Institute) - found that when a type of immune cell called a
dendritic cells recognises a threat, it makes a molecule called
CLEC-2 that tells the scaffold cells within the lymph nodes to
stretch out and expand. This allows an influx of disease fighting
cells. It has long been known that these same dendritic cells
patrol the body searching for threats and call for reinforcements
to tackle them.
Dr Caetano Reis e Sousa of LRI, said: "This important research
helps us unravel how the immune system works and its role in
diseases. We've shown for the first time the dual role of dendritic
cells in responding to infection - both recognising that there is a
threat in the body but also telling the lymph nodes to stretch out.
This expansion of the lymph nodes, the command centres of the
immune system, gives more room for immune cells to gather and
launch their attack against infections and cancer."
Dr Sophie Acton, a Henry Wellcome Postdoctoral Fellow at
University College London visiting Dr Reis e Sousa's lab, said:
"The more we understand about how the immune system recognises and
responds to disease the better we can start to prevent it. We need
to now see if this is the same mechanism that is used in the immune
system's response to cancer and how we can exploit it to fight the
disease."
The paper, Dendritic cells control fibroblastic reticular network tension and
lymph node expansion, is published inNature.