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Breadcrumb Adrian Hayday Hayday lab Immunosurveillance Laboratory : Publications Lab contentLab contentIn this section Overview Exhibit at the Royal Society Vacancies Areas of interest Publications Members Gut Gamma Delta T cells detected by their expression of TCR delta chain RNA (red) line the human colonic epithelium (DAPI; blue) where they are well-placed to perform frontline immune surveillance. 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Europe (1)Transfusion and Apheresis Science (1)Trends in Immunology (1) Facet Journal Publications Displaying 1 - 20 of 110Last updated : 19 April 2024 03:54 Accelarated immune ageing is associated with COVID-19 disease severity Authors (24) JM Lord T Veenith J Sullivan A Sharma-Oates AG Richter NJ Greening[...] O Elneima PJM Openshaw NA Duggal PHOSPCOVID Study collaborative group ISARIC4C investigators Immunity and Ageing Published 11 January 2024 Crick labsAdrian HaydayFull details PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials Authors (16) Pierre Vantourout Josephine Eum María Conde Poole Thomas S Hayday Adam G Laing Khiyam Hussain[...] Roya Servattalab Jonathan Hsu Andrew Bayliffe Madan KatragaddaAdrian Hayday Science advances Published 8 December 2023 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details Long COVID research: an update from the PHOSP-COVID Scientific Summit Authors (6) Christopher E Brightling Rachael A Evans Amisha Singapuri Nikki Smith Louise V Wain PHOSP-COVID Collaborative Group The Lancet Respiratory Medicine Published 1 November 2023 Crick labsAdrian HaydayFull details NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis Authors (22) Sonja Marinović Maja Lenartić Karlo Mladenić Marko Šestan Inga Kavazović Ante Benić[...]Adrian Hayday Sonia Tugues Burkhard Becher Bojan Polić Felix M Wensveen Science Immunology Published 29 September 2023 Crick labsAdrian HaydayFull details Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study Authors (1) C-MORE/PHOSP-COVID Collaborative Group The Lancet Respiratory Medicine Published 1 November 2023 Crick labsAdrian HaydayFull details Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Authors (15)Miguel Munoz-Ruiz Miriam LlorianRocco D'Antuono Anna PavlovaAnna Maria MavrigiannakiDuncan McKenzie[...] Daniel Davies Mariam Jamal-Hanjani Anett Jandke Dmitry S UshakovAdrian Hayday Journal of Allergy and Clinical Immunology Published 1 December 2023 Crick labs/ facilitiesVassilis PachnisAdrian HaydayLight MicroscopyBioinformatics and BiostatisticsFull details β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Authors (32) Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Anastasia Georgakopoulou Hannah Hayman[...] Philip D Dunne Joanne EdwardsAdrian Hayday Owen J Sansom Seth B Coffelt Cancer Immunology Research Published 1 August 2023 Crick labsAdrian HaydayFull details Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls Authors (37) B Zheng G Vivaldi L Daines OC Leavy M Richardson O Elneima[...] RA Evans CE Brightling A Martineau A Sheikh The PHOSP-COVID Study Collaborative Group The Lancet Regional Health - Europe Published 1 June 2023 Crick labsMarkus RalserAdrian HaydayFull details Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity Authors (20) Diego von Werdt Bilgi Gungor Juliana Barreto de Albuquerque Thomas Gruber Daniel Zysset Cheong KC Kwong Chung[...] Gleb Turchinovich Daniela FinkeAdrian Hayday Nadia Corazza Christoph Mueller Frontiers in Immunology Published 20 April 2023 Crick labsAdrian HaydayFull details Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study Authors (62) Callum Jackson Iain D Stewart Tatiana Plekhanova Peter S Cunningham Andrew L Hazel Bashar Al-Sheklly[...] Rachael A Evans Samuel E Jones Martin K Rutter John F Blaikley PHOSP-COVID Study Collaborative Group The Lancet Respiratory Medicine Published 1 August 2023 Crick labsMarkus RalserAdrian HaydayFull details Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study Authors (38) HJC McAuley RA Evans CE Bolton CE Brightling JD Chalmers AB Docherty[...] J Whitney MD Witham J Lord NJ Greening The PHOSP-COVID Study Collaborative Group EClinicalMedicine Published 1 March 2023 Crick labsMarkus RalserAdrian HaydayFull details Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details The effects of clonal heterogeneity on cancer immunosurveillance Authors (3)Krijn Dijkstra Yin WuCharles Swanton Annual Review of Cancer Biology Published 1 April 2023 Crick labsCharles SwantonAdrian HaydayFull details Prolidase deficiency causes spontaneous T cell activation and lupus-like autoimmunity Authors (16) Rose Hodgson Tanya L Crockford Aneesha Bhandari Jessica D Kepple Jennifer Back Eleanor Cawthorne[...] Gordon DouganAdrian Hayday Mukta Deobagkar-Lele Richard J Cornall Katherine R Bull Journal of Immunology Published 1 March 2023 Crick labsAdrian HaydayFull details Durable CD8 T cell memory against SARS-CoV-2 by prime/boost and multi-dose vaccination: Considerations on inter-dose time intervals Authors (6)Ambra Natalini Sonia Simonetti Carmel Sher Ugo D'OroAdrian Hayday Francesca Di Rosa International Journal of Molecular Sciences Published 19 November 2022 Crick labsAdrian HaydayFull details Boosting of waned humoral and cellular responses to SARS-CoV-2 variants of concern among patients with cancer Authors (19)Duncan McKenzie Rosalind Graham Thomas Lechmere Clara Domingo-Vila Thanussuyah Alaguthurai Celeste Arman[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Research Communications Published 1 November 2022 Crick labsAdrian HaydayFull details Antibodies as drugs—a Keystone Symposia report Authors (31) Jennifer Cable Erica Ollmann SaphireAdrian Hayday Timothy D Wiltshire Jarrod J Mousa David P Humphreys[...] Rachael M Wolters Cecile AW Geuijen Matthew A Sleeman Niccolo Pengo Francesca Rose Donnellan Annals of the New York Academy of Sciences Published 1 January 2023 Crick labsAdrian HaydayFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Accelarated immune ageing is associated with COVID-19 disease severity Authors (24) JM Lord T Veenith J Sullivan A Sharma-Oates AG Richter NJ Greening[...] O Elneima PJM Openshaw NA Duggal PHOSPCOVID Study collaborative group ISARIC4C investigators Immunity and Ageing Published 11 January 2024 Crick labsAdrian HaydayFull details
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials Authors (16) Pierre Vantourout Josephine Eum María Conde Poole Thomas S Hayday Adam G Laing Khiyam Hussain[...] Roya Servattalab Jonathan Hsu Andrew Bayliffe Madan KatragaddaAdrian Hayday Science advances Published 8 December 2023 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
Long COVID research: an update from the PHOSP-COVID Scientific Summit Authors (6) Christopher E Brightling Rachael A Evans Amisha Singapuri Nikki Smith Louise V Wain PHOSP-COVID Collaborative Group The Lancet Respiratory Medicine Published 1 November 2023 Crick labsAdrian HaydayFull details
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis Authors (22) Sonja Marinović Maja Lenartić Karlo Mladenić Marko Šestan Inga Kavazović Ante Benić[...]Adrian Hayday Sonia Tugues Burkhard Becher Bojan Polić Felix M Wensveen Science Immunology Published 29 September 2023 Crick labsAdrian HaydayFull details
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study Authors (1) C-MORE/PHOSP-COVID Collaborative Group The Lancet Respiratory Medicine Published 1 November 2023 Crick labsAdrian HaydayFull details
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Authors (15)Miguel Munoz-Ruiz Miriam LlorianRocco D'Antuono Anna PavlovaAnna Maria MavrigiannakiDuncan McKenzie[...] Daniel Davies Mariam Jamal-Hanjani Anett Jandke Dmitry S UshakovAdrian Hayday Journal of Allergy and Clinical Immunology Published 1 December 2023 Crick labs/ facilitiesVassilis PachnisAdrian HaydayLight MicroscopyBioinformatics and BiostatisticsFull details
β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Authors (32) Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Anastasia Georgakopoulou Hannah Hayman[...] Philip D Dunne Joanne EdwardsAdrian Hayday Owen J Sansom Seth B Coffelt Cancer Immunology Research Published 1 August 2023 Crick labsAdrian HaydayFull details
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls Authors (37) B Zheng G Vivaldi L Daines OC Leavy M Richardson O Elneima[...] RA Evans CE Brightling A Martineau A Sheikh The PHOSP-COVID Study Collaborative Group The Lancet Regional Health - Europe Published 1 June 2023 Crick labsMarkus RalserAdrian HaydayFull details
Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity Authors (20) Diego von Werdt Bilgi Gungor Juliana Barreto de Albuquerque Thomas Gruber Daniel Zysset Cheong KC Kwong Chung[...] Gleb Turchinovich Daniela FinkeAdrian Hayday Nadia Corazza Christoph Mueller Frontiers in Immunology Published 20 April 2023 Crick labsAdrian HaydayFull details
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study Authors (62) Callum Jackson Iain D Stewart Tatiana Plekhanova Peter S Cunningham Andrew L Hazel Bashar Al-Sheklly[...] Rachael A Evans Samuel E Jones Martin K Rutter John F Blaikley PHOSP-COVID Study Collaborative Group The Lancet Respiratory Medicine Published 1 August 2023 Crick labsMarkus RalserAdrian HaydayFull details
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study Authors (38) HJC McAuley RA Evans CE Bolton CE Brightling JD Chalmers AB Docherty[...] J Whitney MD Witham J Lord NJ Greening The PHOSP-COVID Study Collaborative Group EClinicalMedicine Published 1 March 2023 Crick labsMarkus RalserAdrian HaydayFull details
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
The effects of clonal heterogeneity on cancer immunosurveillance Authors (3)Krijn Dijkstra Yin WuCharles Swanton Annual Review of Cancer Biology Published 1 April 2023 Crick labsCharles SwantonAdrian HaydayFull details
Prolidase deficiency causes spontaneous T cell activation and lupus-like autoimmunity Authors (16) Rose Hodgson Tanya L Crockford Aneesha Bhandari Jessica D Kepple Jennifer Back Eleanor Cawthorne[...] Gordon DouganAdrian Hayday Mukta Deobagkar-Lele Richard J Cornall Katherine R Bull Journal of Immunology Published 1 March 2023 Crick labsAdrian HaydayFull details
Durable CD8 T cell memory against SARS-CoV-2 by prime/boost and multi-dose vaccination: Considerations on inter-dose time intervals Authors (6)Ambra Natalini Sonia Simonetti Carmel Sher Ugo D'OroAdrian Hayday Francesca Di Rosa International Journal of Molecular Sciences Published 19 November 2022 Crick labsAdrian HaydayFull details
Boosting of waned humoral and cellular responses to SARS-CoV-2 variants of concern among patients with cancer Authors (19)Duncan McKenzie Rosalind Graham Thomas Lechmere Clara Domingo-Vila Thanussuyah Alaguthurai Celeste Arman[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Research Communications Published 1 November 2022 Crick labsAdrian HaydayFull details
Antibodies as drugs—a Keystone Symposia report Authors (31) Jennifer Cable Erica Ollmann SaphireAdrian Hayday Timothy D Wiltshire Jarrod J Mousa David P Humphreys[...] Rachael M Wolters Cecile AW Geuijen Matthew A Sleeman Niccolo Pengo Francesca Rose Donnellan Annals of the New York Academy of Sciences Published 1 January 2023 Crick labsAdrian HaydayFull details