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Breadcrumb Richard Treisman Treisman lab Signalling and Transcription Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Background picture shows a surface representation of the MRTF-A / G-actin complex (Mouilleron et al, Science Signalling 2011). Red and black, RPEL domain sequences; other colours, actins. Image, Stéphane Mouilleron. Toggle to view hero caption PublicationsYear published2023 (1)2021 (1)2020 (1)2019 (2)2018 (3)2017 (3)2016 (4)2015 (3)2014 (2)2013 (3)2012 (2)2011 (3)2010 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (16)Cell Biology (16)Gene Expression (16)Genetics & Genomics (16)Model Organisms (16)Signalling & Oncogenes (16)Tumour Biology (16)Chemical Biology & High Throughput (5)Computational & Systems Biology (4)Genome Integrity & Repair (3)Structural Biology & Biophysics (3)Developmental Biology (1)Human Biology & Physiology (1)Imaging (1)Neurosciences (1)Stem Cells (1) Facet Research topicsPublication typeJournal article (30)Primary research (27)Commentary (1)Editorial (1)Review (1) Facet Publication typeJournaleLife (2)EMBO Journal (2)Genes & Development (2)Journal of Immunology (2)Molecular Cell (2)Science (2)Blood (1)Cell (1)Cell systems (1)Chemical Science (1)Clinical Genetics (1)Crystals (1)EMBO Reports (1)Gastroenterology (1)Investigative ophthalmology & visual science (1)Journal of Cell Science (1)Molecular and Cellular Biology (1)Nature Cell Biology (1)Nature Communications (1)Science Signaling (1)Scientific Reports (1)Structure (1)The FASEB Journal (1)Trends in Biochemical Sciences (1) Facet Journal Publications Displaying 1 - 20 of 30Last updated : 28 March 2024 02:24 Discovery of lipid-mediated protein–protein interactions in living cells using metabolic labeling with photoactivatable clickable probes Authors (6)Roman Fedoryshchak Andrii Gorelik Mengjie Shen Maria M Shchepinova Inmaculada Pérez-Dorado Edward W Tate Chemical Science Published 7 March 2023 Crick labsRichard TreismanEd TateFull details Mutation in PHACTR1 associated with multifocal epilepsy with infantile spasms and hypsarrhythmia Authors (11) Andrey V Marakhonov Magdalena Přechová Fedor A Konovalov Alexandra Yu Filatova Maria A Zamkova Ilya V Kanivets Vladimir G Solonichenko Natalia A Semenova Rena A ZinchenkoRichard Treisman Mikhail Yu Skoblov Clinical Genetics Published 1 May 2021 Crick labs/ facilitiesRichard TreismanStructural BiologyFull details Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme Authors (11)Roman Fedoryshchak Magdalena Přechová Abbey M Butler Rebecca LeeNicola O'Reilly Helen R FlynnBram SnijdersNoreen EderSila UltanirStephane MouilleronRichard Treisman eLife Published 25 September 2020 Crick labs/ facilitiesSila UltanirRichard TreismanStructural BiologyProteomicsLight MicroscopyFermentationBiological Research FacilityAdvanced SequencingFull details Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1) Authors (5) Syed Rydwan Ali Taylor Joseph Malone Yalan Zhang Magdalena Prechova Leonard Konrad Kaczmarek The FASEB Journal Published 3 January 2020 Crick labsRichard TreismanFull details RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Authors (4)Jessica DiringStephane MouilleronNeil McDonaldRichard Treisman Nature Cell Biology Published 1 July 2019 Crick labs/ facilitiesRichard TreismanNeil McDonaldStructural BiologyLight MicroscopyHigh Throughput ScreeningFlow CytometryFermentationBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details ERK signaling controls innate-like CD8+ T cell differentiation via the ELK4 (SAP-1) and ELK1 transcription factors Authors (4) Diane MauricePatrick Costello Mathew SargentRichard Treisman Journal of Immunology Published 15 September 2018 Crick labs/ facilitiesRichard TreismanFlow CytometryBiological Research FacilityFull details Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export Authors (8) Nil EgeAnna DowbajMing JiangMichael HowellSteven Hooper Charles FosterRob JenkinsErik Sahai Cell systems Published 27 June 2018 Crick labs/ facilitiesRichard TreismanErik SahaiHigh Throughput ScreeningFull details Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics Authors (3) Charles Foster Francesco GualdriniRichard Treisman Genes & Development Published 9 January 2018 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsFull details A novel approach to data collection for difficult structures: Data management for large numbers of crystals with the BLEND software Authors (7) Anastasia Mylona S Carr P Aller I MoraesRichard Treisman G Evans J Foadi Crystals Published 4 August 2017 Crick labsRichard TreismanFull details Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis Authors (10) Cynthia Yu-Wai Man Bradley Spencer-Dene Richard MH Lee Kim Hutchings Erika M LisabethRichard Treisman Maryse Bailly Scott D Larsen Richard R Neubig Peng T Khaw Scientific Reports Published 31 March 2017 Crick labs/ facilitiesRichard TreismanExperimental HistopathologyFull details ERK-induced activation of TCF family of SRF cofactors initiates a chromatin modification cascade associated with transcription Authors (8) Cyril Esnault Francesco Gualdrini Stuart HorswellGavin KellyAengus StewartPhil East Nik MatthewsRichard Treisman Molecular Cell Published 16 March 2017 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsAdvanced SequencingFull details SRF co-factors control the balance between cell proliferation and contractility Authors (6) Francesco Gualdrini Cyril Esnault Stuart HorswellAengus Stewart Nik MatthewsRichard Treisman Molecular Cell Published 15 December 2016 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningFull details Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation Authors (8) Anastasia Mylona Francois-Xavier Theillet Charles Foster Tammy M Cheng Francesc MirallesPaul Bates Philipp SelenkoRichard Treisman Science Published 14 October 2016 Crick labs/ facilitiesRichard TreismanPaul BatesFlow CytometryAdvanced SequencingFull details Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity Authors (7) Richard Panayiotou Francesc Miralles Rafal PawlowskiJessica Diring Helen R FlynnMark SkehelRichard Treisman eLife Published 15 June 2016 Crick labs/ facilitiesRichard TreismanProteomicsHigh Throughput ScreeningAdvanced SequencingFull details YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK-STAT3 signaling Authors (6) Ralph Gruber Richard PanayiotouEmma Nye Bradley Spencer-Dene Gordon StampAxel Behrens Gastroenterology Published 1 September 2016 Crick labs/ facilitiesRichard TreismanAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells Authors (9) Katrin E Wiese Heidi M Haikala Björn von Eyss Elmar Wolf Cyril Esnault Andreas RosenwaldRichard Treisman Juha Klefström Martin Eilers EMBO Journal Published 3 June 2015 Crick labsRichard TreismanFull details RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1 Authors (6) Eeva Kaisa Rajakylä Tiina Viita Salla Kyheröinen Guillaume HuetRichard Treisman Maria K Vartiainen Nature Communications Published 14 January 2015 Crick labsRichard TreismanFull details MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development Authors (7)Patrick Costello Mathew Sargent Diane Maurice Cyril Esnault Katie FosterFernando Dos Anjos AfonsoRichard Treisman Blood Published 19 February 2015 Crick labsRichard TreismanDominique BonnetFull details The role of the MRTF-A/SRF pathway in ocular fibrosis Authors (4) Cynthia Yu-Wai-ManRichard Treisman Maryse Bailly Peng Tee Khaw Investigative ophthalmology & visual science Published 1 July 2014 Crick labsRichard TreismanFull details Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts Authors (7) Cyril EsnaultAengus Stewart Francesco GualdriniPhil East Stuart Horswell Nik MatthewsRichard Treisman Genes & Development Published 1 May 2014 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Discovery of lipid-mediated protein–protein interactions in living cells using metabolic labeling with photoactivatable clickable probes Authors (6)Roman Fedoryshchak Andrii Gorelik Mengjie Shen Maria M Shchepinova Inmaculada Pérez-Dorado Edward W Tate Chemical Science Published 7 March 2023 Crick labsRichard TreismanEd TateFull details
Mutation in PHACTR1 associated with multifocal epilepsy with infantile spasms and hypsarrhythmia Authors (11) Andrey V Marakhonov Magdalena Přechová Fedor A Konovalov Alexandra Yu Filatova Maria A Zamkova Ilya V Kanivets Vladimir G Solonichenko Natalia A Semenova Rena A ZinchenkoRichard Treisman Mikhail Yu Skoblov Clinical Genetics Published 1 May 2021 Crick labs/ facilitiesRichard TreismanStructural BiologyFull details
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme Authors (11)Roman Fedoryshchak Magdalena Přechová Abbey M Butler Rebecca LeeNicola O'Reilly Helen R FlynnBram SnijdersNoreen EderSila UltanirStephane MouilleronRichard Treisman eLife Published 25 September 2020 Crick labs/ facilitiesSila UltanirRichard TreismanStructural BiologyProteomicsLight MicroscopyFermentationBiological Research FacilityAdvanced SequencingFull details
Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1) Authors (5) Syed Rydwan Ali Taylor Joseph Malone Yalan Zhang Magdalena Prechova Leonard Konrad Kaczmarek The FASEB Journal Published 3 January 2020 Crick labsRichard TreismanFull details
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Authors (4)Jessica DiringStephane MouilleronNeil McDonaldRichard Treisman Nature Cell Biology Published 1 July 2019 Crick labs/ facilitiesRichard TreismanNeil McDonaldStructural BiologyLight MicroscopyHigh Throughput ScreeningFlow CytometryFermentationBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
ERK signaling controls innate-like CD8+ T cell differentiation via the ELK4 (SAP-1) and ELK1 transcription factors Authors (4) Diane MauricePatrick Costello Mathew SargentRichard Treisman Journal of Immunology Published 15 September 2018 Crick labs/ facilitiesRichard TreismanFlow CytometryBiological Research FacilityFull details
Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export Authors (8) Nil EgeAnna DowbajMing JiangMichael HowellSteven Hooper Charles FosterRob JenkinsErik Sahai Cell systems Published 27 June 2018 Crick labs/ facilitiesRichard TreismanErik SahaiHigh Throughput ScreeningFull details
Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics Authors (3) Charles Foster Francesco GualdriniRichard Treisman Genes & Development Published 9 January 2018 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsFull details
A novel approach to data collection for difficult structures: Data management for large numbers of crystals with the BLEND software Authors (7) Anastasia Mylona S Carr P Aller I MoraesRichard Treisman G Evans J Foadi Crystals Published 4 August 2017 Crick labsRichard TreismanFull details
Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis Authors (10) Cynthia Yu-Wai Man Bradley Spencer-Dene Richard MH Lee Kim Hutchings Erika M LisabethRichard Treisman Maryse Bailly Scott D Larsen Richard R Neubig Peng T Khaw Scientific Reports Published 31 March 2017 Crick labs/ facilitiesRichard TreismanExperimental HistopathologyFull details
ERK-induced activation of TCF family of SRF cofactors initiates a chromatin modification cascade associated with transcription Authors (8) Cyril Esnault Francesco Gualdrini Stuart HorswellGavin KellyAengus StewartPhil East Nik MatthewsRichard Treisman Molecular Cell Published 16 March 2017 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsAdvanced SequencingFull details
SRF co-factors control the balance between cell proliferation and contractility Authors (6) Francesco Gualdrini Cyril Esnault Stuart HorswellAengus Stewart Nik MatthewsRichard Treisman Molecular Cell Published 15 December 2016 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningFull details
Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation Authors (8) Anastasia Mylona Francois-Xavier Theillet Charles Foster Tammy M Cheng Francesc MirallesPaul Bates Philipp SelenkoRichard Treisman Science Published 14 October 2016 Crick labs/ facilitiesRichard TreismanPaul BatesFlow CytometryAdvanced SequencingFull details
Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity Authors (7) Richard Panayiotou Francesc Miralles Rafal PawlowskiJessica Diring Helen R FlynnMark SkehelRichard Treisman eLife Published 15 June 2016 Crick labs/ facilitiesRichard TreismanProteomicsHigh Throughput ScreeningAdvanced SequencingFull details
YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK-STAT3 signaling Authors (6) Ralph Gruber Richard PanayiotouEmma Nye Bradley Spencer-Dene Gordon StampAxel Behrens Gastroenterology Published 1 September 2016 Crick labs/ facilitiesRichard TreismanAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells Authors (9) Katrin E Wiese Heidi M Haikala Björn von Eyss Elmar Wolf Cyril Esnault Andreas RosenwaldRichard Treisman Juha Klefström Martin Eilers EMBO Journal Published 3 June 2015 Crick labsRichard TreismanFull details
RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1 Authors (6) Eeva Kaisa Rajakylä Tiina Viita Salla Kyheröinen Guillaume HuetRichard Treisman Maria K Vartiainen Nature Communications Published 14 January 2015 Crick labsRichard TreismanFull details
MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development Authors (7)Patrick Costello Mathew Sargent Diane Maurice Cyril Esnault Katie FosterFernando Dos Anjos AfonsoRichard Treisman Blood Published 19 February 2015 Crick labsRichard TreismanDominique BonnetFull details
The role of the MRTF-A/SRF pathway in ocular fibrosis Authors (4) Cynthia Yu-Wai-ManRichard Treisman Maryse Bailly Peng Tee Khaw Investigative ophthalmology & visual science Published 1 July 2014 Crick labsRichard TreismanFull details
Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts Authors (7) Cyril EsnaultAengus Stewart Francesco GualdriniPhil East Stuart Horswell Nik MatthewsRichard Treisman Genes & Development Published 1 May 2014 Crick labs/ facilitiesRichard TreismanBioinformatics and BiostatisticsAdvanced SequencingFull details