We are a computational biology laboratory with a particular interest in the genome-scale analysis of gene regulation and evolution. Our goal is to use genomic data to understand:
- How is gene expression regulated?
- How do these mechanisms control interesting biological behaviours, including diseases?
- How does gene regulation affect evolution?
We use a genomic approach as it allows us to identify common principles that apply to most biological systems. Unique or unusual cases - which always occur in biology - could then be understood within this broader context. Most of our work depends on publicly available data, but we also collaborate closely with experimental laboratories.