Cancer evolution and genome instability

Research opportunity for a postdoctoral clinical fellow in Charles Swanton's lab.

Introduction

My lab is interested in the mechanistic basis of cell to cell variation in cancer that fuels natural selection, adaptations and ultimately drug resistance.

We are studying cancer evolution in the TRACERx longitudinal programs in Renal and non-small cell lung cancer to understand the origins of the lethal metastatic subclones, whether evolutionary trajectories can be predicted and monitored in real time, how the immune system constrains cancer genome evolution and adaptation and the underlying drivers of branched Darwinian and Macroevolution in cancer.

The goal of our lab is to develop insights that will lead to new approaches to limit tumour evolution and adaptation within clinical trials.