Introduction
My lab is interested in the mechanistic basis of cell to cell variation in cancer that fuels natural selection, adaptations and ultimately drug resistance, how tumours evade immune-mediated predation during evolution and how environmental carcinogens trigger cancer initiation.
We are studying cancer evolution in the TRACERx longitudinal programs in non-small cell lung cancer to understand the origins of the lethal metastatic subclones, whether evolutionary trajectories can be predicted and monitored in real time, how the immune system constrains cancer genome evolution and adaptation and the underlying drivers of cancer initiation, branched Darwinian and Macroevolution in cancer.
The goal of our lab is to develop insights that will lead to new approaches to limit tumour initiation, evolution and adaptation within clinical trials.
