We are interested in elucidating the interactions between cancer and the nervous system. In particular, we aim to reveal how tumour innervation may affect cancer progression, and whether interfering with such a crosstalk could provide novel inroads for cancer therapy.
We use a variety of highly translational genetically-engineered mouse models of cancer as our principal platforms of investigation. We will employ a wide range of advanced techniques to interrogate the role of innervation in tumour progression, including single cell transcriptomics, optogenetics, chemogenetics, neural circuit-tracing techniques, intravital imaging, etc..
Clinicians who are passionate in understanding the basic mechanisms of cancer progression and enthusiastic about developing novel therapeutic options for cancer patients are welcome to join us.