Cancer relapse and therapeutic resistance

Research opportunity for a postdoctoral clinical fellow in Dinis Calado’s lab.

The project

The immunity and cancer laboratory investigates the molecular pathways of immune cell development and their contribution to the pathogenesis and therapy resistance of haematological malignancies with focus in lymphoma and multiple myeloma.
 
The laboratory has in place model systems in the mouse that mimic human disease therapy resistance in a fully immunocompetent environment. Using these systems we investigate the intrinsic and extrinsic mechanisms of therapy resistance using advanced technologies, including longitudinal analysis of cancer cells and microenvironment by single cell RNA-sequencing, imaging, flow and mass cytometry.