We are interested in how cells respond to dissipation of intracellular pH gradients. This occurs in response to a variety of inflammatory stimuli, for example during infection by influenza. It triggers a pathway related to autophagy, as well as inflammasome activation. We are exploring the relationship between these responses, and their contribution to pathophysiology.
Clinicians broadly interested in inflammation, infection or immunity would be welcome to discuss projects. My own medical speciality is nephrology, but I would welcome applications from any clinicians with laboratory experience.