Chromosome replication

Research opportunity for a postdoctoral clinical fellow in John Diffley's lab.


We aim to understand all aspects of DNA replication. 

We use biochemical approaches with purified proteins to elucidate the mechanism of replication, and cell biology and genetics with human cells to characterise how DNA replication is regulated.

In addition, we are especially interested in understanding how deregulation of the cell cycle and of cell signalling in cancer leads to replicative stress, and how replicative stress leads to increased genetic variability in tumours.