The Genome Function Laboratory studies the genetic mechanisms by which mutations lead to cancer.
We develop high-throughput genome editing assays to study large numbers of variants in critical cancer genes. Our goal is to generate functional data that allows us to confidently predict how every genetic variant we encounter in a patient will impact their disease – from the chance of developing cancer to responses to targeted therapies. We calibrate our functional studies in human cell lines to clinical evidence of variant effect. As our methods continue to improve in scale and resolution, we will directly advance patient care by enabling precision medicine approaches.