Introduction
We are investigating the molecular program that regulate both human normal stem cells and how oncogenic events impede the normal hematopoietic stem cell development both directly and via the stem cell environment.
We are particular focusing on myeloid initiating and propagating cells in the context of myeloid leukemia (MDS and AML) and how to targets these cells. We make use of single cell RNA seq, intravital imaging and 3D humanised scaffold to study the interactions between HSC/LSC with their microenvironment and CRISP/Cas or lentivirus to study the function of genes or mutations.
