Proteases in host cell exit and invasion by the malaria parasite

Research opportunity for a postdoctoral clinical fellow in Mike Blackman's lab.

Introduction

Our group studies the basic biology of the malaria parasite Plasmodium falciparum, with a focus on how the parasite enters and exits host red blood cells.

The resulting red cell modifications and destruction lead to anaemia, vascular dysfunction and other pathology associated with the disease. We use biochemical and reverse genetic approaches to understand the molecular mechanisms used by the parasite to exploit this unusual cellular niche. A particular current interest is a parasite enzyme pathway that leads to destabilisation and rupture of the red cell cytoskeleton.