Our lab studies signalling control in intestinal stem cell and cancer, with the emphasis on finding new tumour-specific therapeutic targets. With the use of mouse genetics and organoid technology, we have recently uncovered a number of Wnt pathway regulators that play important role in intestinal development and colorectal cancer (CRC) progression, which could present new therapeutic strategies for CRC.
We are currently exploring the link between Wnt signalling and immunosuppression in CRC. Despite promising results of immunotherapies in the clinic, the response rate is very low in CRC. Our aim is to identify the mechanism underlying the immunotherapy efficacy in CRC and to develop effective treatment. We also investigate biomarkers for early CRC diagnosis.