My lab works on symmetry-breaking and cell polarity - essentially how cells acquire their sense of direction. Cell polarity networks play critical roles in the organisation of cells and tissues from the earliest stages of animal development and are often disregulated in diseases such as cancer.
We typically use the embryo of the nematode C. elegans as a model to understand the design principles of cell polarity networks that permit and define intracellular patterning. To this end, we combine techniques from genetics and pharmacology with advanced imaging and mathematical modelling. We are particularly interested in understanding the underlying feedback circuits that drive polarised patterning of the cell, how these molecules interface with cytoskeletal networks that can re-organize these networks, and how networks adapt to changes in size, shape and environmental stress.