Systems chemical biology of antibiotic resistance evolution

Research opportunity for a postdoctoral clinical fellow in Eachan Johnson’s lab.

The project

How do pathogenic bacteria seem to inevitably evolve resistance to antibiotics? We use high throughput quantitative genetics to answer this question in Mycobacterium tuberculosis and Klebsiella pneumoniae, and develop chemical tools as a complement to genetics to understand how to manipulate the evolution of antibiotic resistance.

Clinicians interested in microbiology and infectious disease are welcome to discuss possible projects, which could include quantitative genetic and chemical screens, mechanism of action elucidation of small molecules, and applying machine learning approaches to large chemical-genetic datasets.