About the placements
Different sequences of amino acids in proteins give rise to very different three-dimensional shapes and functions. These proteins may then interact with one another to form protein complexes. The proteins or proteins complexes can also be bound to other molecules like DNA, RNA or carbohydrates.
The Structural Biology Platform is a facility providing support to scientists to study the structure and function of proteins and protein complexes using methods such as protein purification, crystallisation, and X-ray data collection and analysis.
Such knowledge helps scientists to develop new ways of tackling diseases, for example by blocking the viral entry points of a cell or identifying weak points that can be targeted by drugs.
The successful candidate will be working on the HUSH complex which is involved in gene silencing (switching genes off), a mechanism involved in epigenetics.
There are two positions available for this placement in the Structural Biology Platform.
It is expected that all students accepted for a placement at the Crick are punctual, responsible, show a willingness to learn, listen to advice and act on feedback. Candidates for these positions should also:
- be interested in protein chemistry,
- be a team player, and
- be inquisitive.