Cellular mechanisms underlying brain volume changes

Research opportunity for a postdoctoral clinical fellow in Jonny Kohl’s lab.

The project

My lab is interested in how internal states shape the form and function of neural circuits. We use a multidisciplinary approach, combining cutting-edge methods in circuit neuroscience, behavioural profiling, and molecular and cellular biology. 

We are looking for a clinician scientist interested in uncovering the cellular mechanisms behind pregnancy-induced brain volume changes. We recently identified pronounced volumetric changes in the mouse brain in late pregnancy, and have evidence suggesting that these changes are due to hormonal action on specific brain areas and circuits. Similar, long-lasting grey matter volume changes have been identified in humans, where they are associated with later parental attachment.

Our mouse model offers the unique opportunity to address the cellular causes – and functional consequences – of such volumetric changes. This project will involve multimodal imaging methods and computational image analysis, as well as systems neuroscience approaches to manipulate identified plasticity mechanisms. However, the exact strategy will be developed with the successful applicant. Understanding these mechanisms will provide us with exciting insights into how hormonal changes affect brain structure and function in health and disease.