The Project
Our lab is interested in uncovering the pathogenic mechanisms that lead to human autoimmune disease. Using non-coding genetic variants as a starting point, we have developed methods to identify the molecular, cellular, and immunological pathways that contribute to immune-mediated disease, and investigate whether these could provide opportunities for new therapies. Current work uses primary human CD4+ and CD8+ T cells (including Tregs and Th17 subsets), monocytes, macrophages and NK cells, as well as mouse models.
Clinicians with an interest in autoimmune / inflammatory disease mechanisms are encouraged to discuss potential projects.
