Senior Laboratory Research Scientist in Alessandro Costa's Molecular Machines group

The Senior Laboratory Research Scientist (SLRS) will be involved in research projects on the structural mechanism of chromosome replication in eukaryotic cells. The SLRS will also help with training junior group members and with the day-to-day running of the laboratory.
Deadline for applications has passed.

Key information

Job reference
R48
Salary
Competitive with benefits, subject to skills and experience.
Applications closed
01 May 2021, 00:00 BST
Hours per week
36 (full time)
Posted 25 March 2021

Job title:

  • Senior Laboratory Research Scientist in Alessandro Costa's Molecular Machines group

Closing date and time:

  • 30 April 2021, 23:59

Reports to:

  • Alessandro Costa

Contract term:

  • This is a full-time and permanent position on Crick terms and conditions of employment.

Project summary

We are looking for an experienced researcher passionate about molecular mechanisms. The candidate will be involved in collaborative research projects, will help with training junior lab members in protein biochemistry and structural biology, and help with the day-to-day running of the lab.

The Molecular Machines laboratory focuses on understanding the mechanism of chromosome replication using biochemical reconstitution and cryo-electron microscopy. Details of research projects currently being undertaken can be seen at:  https://www.crick.ac.uk/research/labs/alessandro-costa and https://www.alecostalab.net/

Key responsibilities

These include but are not limited to:

  • Designing and conducting scientific experiments independently or in collaboration with other group members.
  • Cloning, expressing and purifying multi-component protein assemblies.
  • Conducting chromosome replication reactions to be monitored biochemically, or using light and cryo-electron microscopy.
  • Training junior lab members in protein biochemistry and structural biology techniques.
  • Helping with the day-to-day running of the lab, including organising lab space and ordering consumables.

Key experience and competencies

Essential

  • PhD in Biochemistry, Structural Biology (and related fields) or in the final stages of PhD submission.
  • Knowledge and experience in molecular cloning, protein expression and purification.
  • Experience in experimental design.
  • Ability to work independently and in collaboration with other group members.

Desirable

Different profiles will be a suitable fit in the lab. These include individuals with experience in

  • conducting enzymatic assays (e.g. nucleic acid polymerasation, kinase and ATPase).
  • nucleosome reconstitution and chromatin biology.
  • atomic model building.
  • working with Unix and coding in Python.
  • Cryo-EM.
  • Single-molecule fluorescence microscopy.