Senior Research Scientist - Cancer Dynamics Laboratory

Applies an in-depth knowledge of research, technical or other scientific practices, methods and procedures gained through either experience and/or formal academic qualifications and applies this knowledge to provide a range of specialist activities. Senior Laboratory Research Scientist is the level at which careers in this functional family typically stabilise.
Deadline for applications has passed.

Key information

Job reference
R227
Salary
Competitive with benefits, subject to skills and experience.
Applications closed
18 June 2021, 00:00 BST
Hours per week
36 (full time)
Posted 20 May 2021

Job title: Senior Research Scientist

Closing date and time: 17 June 23:59

Contact term: This is a full-time, permanent position on Crick terms and conditions of employment.

Reports to: Samra Turajlic, Group Leader

Summary

We are looking for a highly motivated and experienced senior research scientist to join our multidisciplinary group focused on a multi-faceted understanding of cancer evolution with the ultimate aim of improving the outcomes of cancer patients. The post-holder will contribute to the programme through involvement and oversight of a variety of projects (details below) with substantial scope for academic independence, judgement, originality, interpretation and presentation of results with full authority for many aspects of the work. The post-holder, if they choose to, can also lead their own research question/project as agreed with the PI. The post-holder will provide guidance and supervision for junior scientists, including students and post-docs and participate in multiple scientific interactions with scientific collaborative partners within the Crick Institute, including Science Technology Platforms (STPs), and other research groups,  as well as the clinical research team at the Royal Marsden NHS Foundation Trust and our other affiliated clinical sites. The post-holder will have the opportunity to engage with our international collaborators, both academic and industry, and take a leadership role in these collaborations where appropriate. There will be ample opportunities for personal development, including training in both technical and non-technical domains while attendance of national and international conferences will be strongly supported. Given the inter-disciplinary nature of our work the applicant needs to be exceptionally organised, dynamic, an excellent team-player and able to adapt to emerging needs of our research programme.

Project summary

Our research programme is embedded in unique large-scale translational studies (for further details please visit our lab website https://www.crick.ac.uk/research/labs/samra-turajlic/areas-of-interest), aimed at understanding cancer evolution and cancer dynamics. We pride ourselves in responding to emerging questions relevant to cancer patients, one recent example being the Capture study (https://www.royalmarsden.nhs.uk/capture-covid-19-antiviral-response-pan-tumour-immune-study) examining immune response to  COVID-19. In the next few years we will leverage these studies to also understand the tumour microenvironment (TME), and anti-tumour immune response, using cutting-edge wet-lab techniques, as well as machine learning and mathematical modelling;  pre-clinical models and genome editing. We are a very collegiate, open, friendly and enthusiastic group made up of basic scientists, bioinformaticians and clinical researchers and we interact closely with STPs and other groups at the Crick and national and international collaborators including the Urologic Branch at NIH, as well as pharma partners, especially Roche Diagnostics and BMS. This role would suit an accomplished scientist with background in cancer genetics, molecular biology and/or cancer immunology who would embrace our programme with ambition and enthusiasm and bring their own perspective to our research questions.

Key responsibilities

These include but are not limited to:

  • Undertake laboratory research, developing the assigned projects in a timely and resource efficient manner (design and execute experiments, collect and analyse data)
  • Undertake collaborative projects or new projects for which data are needed to obtain funding/advance publications
  • Provide technical input for the development, refinement and troubleshooting of relevant methodologies
  • Make research initiatives and original contributions to the research programme wherever possible, and to contribute freely to the team research environment in a manner conducive to the success of the research project as a whole
  • Attend and participate in the lab’s academic activities, e.g. laboratory and journal club meetings, research group meetings and wider network meetings
  • Participate in manuscript and funding grant proposal development
  • Support other lab members with their experiments and junior lab members with training
  • Act at the interface with collaborators
  • Oversee research governance in the lab including management of material transfer and collaborative agreements in conjunction with the Crick Legal team
  • Oversee the laboratory budget which includes multiple multimillion external grants
  • Represent the PI at internal meetings, for example STP related

These duties are a guide to the work that the post holder will be required to undertake. They may change from time to time in accordance with new scientific developments.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential Qualifications, experience and competencies:

  • Previous experience of scientific research in a similar role
  • Enthusiasm and motivation to contribute to scientific research
  • Demonstrable understanding of the research process
  • A proven ability to analyse scientific data and make decisions based on this
  • A proven ability to organise and prioritise own work
  • A proven ability to maintain good laboratory records
  • A willingness to learn new skills
  • Initiative to work independently
  • Excellent communication skills
  • A proven ability to work effectively and positively as part of a team and outside of the team
  • Strong collaborative ability and teamwork experience
  • Experience of multi-disciplinary research
  • A proven ability to interpret scientific literature and incorporate into project
  • Experience with designing and setting up experiments in cancer/molecular  biology and functional genomics and/or experience with immunological assays
  • Experience with training and supervising junior scientists
  • Experience with scientific writing, including manuscripts and funding proposals
  • PhD in Immunology or Molecular Biology or Genetics
  • Background in cancer research or immunology or both
  • Experience of translational research
  • Experience of tumour microenvironment studies
  • Experience of preclinical models of cancer
  • Experience with genome editing tecghniques
  • Experience in cancer evolution studies

Informal enquiries relating to this role can be addressed to Samra Turajlic: samra.turajlic@crick.ac.uk

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.