Postdoctoral Training Fellow
Closing date and time:
1st July 2021 at 23:59
This is a full-time, 4-year position on Crick terms and conditions of employment in the Tybulewicz Lab.
The Research Group
The Tybulewicz lab is studying signalling pathways that control the biology of B and T lymphocytes. In particular we are working on pathways that control lymphocyte activation, differentiation, survival, adhesion and migration. We use a broad range of techniques including mouse genetics, biochemistry, imaging, proteomics, transcriptomics and cellular immunology. The lab currently consists of around 13 researchers including PhD students, postdocs and laboratory research scientists. For more information see the lab website.
We have previously shown that the WNK1 kinase regulates T cell migration and adhesion (Köchl et al, 2016. Nat Immunol, 17, 1075-1083). In unpublished work we have found that WNK1 also regulates T cell activation and discovered a novel and unexpected signalling pathway that regulates ion and water flux across the plasma membrane, which is essential for T cell migration and activation, thereby opening up an exciting new area of investigation (Figure).
The proposed research will focus on how the WNK1 pathway and ion and water flux regulate T cell migration and activation. The work will look at the role of ion and water transporters in the regulation of these processes. The postdoc will be able to expand their studies into other areas of signalling in T cells. The work will involve mouse genetics, imaging, biochemistry, CRISPR screens, optogenetics, microfluidics, proteomics or transcriptomics. The work is funded by a BSSRC grant.
These include but are not limited to:
Develop and lead an independent research project
Contribute to work of others in the group and in the wider Crick research community
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
PhD in a relevant area (e.g. immunology, biochemistry) or be in the final stages of PhD submission
Good knowledge and experience of genetics, biochemistry or immunology
Expertise in imaging
Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
Evidence of data presentation at scientific meetings
Experience of experimental design
Ability to work independently and also capable of interacting within a group
Experience in research using mouse genetics
Experience in research on T cells
Expertise in bioinformatics