Laboratory Research Scientist - Histopathology

Applies specific technical or practical skills and has a well-developed working knowledge of technical or scientific practices and procedures acquired through on-the-job, vocational or academic training. Work will involve the application of skills and knowledge to provide a range of technical support activities.

Key information

Job reference
R300
Salary
Competitive with benefits, subject to skills and experience.
Application close date
01 August 2021, 00:00 BST
Hours per week
36 (full time)
Posted 01 July 2021

This is a permanent position on Crick Terms and Conditions of Employment. This is a full-time post.

                  

OVERVIEW

The Francis Crick institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and Kings College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute is a world-leading centre of biomedical research and innovation. It promotes connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute has the scale, vision, and expertise to tackle the most challenging scientific questions underpinning health and disease. It is world-class with a strong national role in training scientists and developing ideas for public good. The Crick is in a new, purpose-built research centre in Brill Place, St. Pancras and houses some 1,500 staff.

As an LRS in Experimental Histopathology (EHP) you will work closely with the Head of EHP and other members of the team to provide an outstanding Histopathology service which supports the scientific aims of the Francis Crick Institute, as well as working with post-docs, students and other scientists, technicians and operations staff across the institute, and scientific partners of the Crick.  The post holder will divide their time between supporting user activities and training, performing techniques in specific technical areas and assisting with day-to-day administration of projects delegated by the Head of EHP-STP and senior EHP staff.

KEY RESPONSIBILITIES

These include but are not limited to;

  • Assistance in the provision of an outstanding histopathology service by providing histology expertise and contribution to the day-to-day operations to ensure the laboratory runs as efficiently as possible and contributing to the team's collective success.
  • Routine laboratory preparation work; sample preparation and processing, embedding, cutting paraffin, frozen and vibratome tissue serial sections; performing histological special stains.
  • Providing Immunohistochemistry (IHC) expertise (multiplexing and optimisations) plus RNAScope in-situ hybridisation (ISH) and assistance on developing projects to improve these technologies, as agreed with the EHP Head and senior staff.
  • Interact with and consult collaboratively with users of the service to help plan experiments where necessary
  • To ensure that own scientific work is carried out accurately and efficiently and by own initiative, as agreed with the head of the EHP STP
  • Liaising with and training other members of the EHP team and researchers on specialist equipment and techniques
  • Communication of lab results at lab meetings and STP talks to keep colleagues informed of developments and lab practices.
  • Ensuring compliance to health and safety regulations. Writing Risk Assessments and Standard operating procedures.
  • To strive for continuous performance improvement and professional development in the fields of histopathology, IHC and ISH by attending courses and workshops, presenting work at scientific meetings, and keeping abreast of the relevant literature and developments in the field

KEY EXPERIENCE AND COMPETENCIES

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

Essential:

  • A degree in biological science, or equivalent research or clinical experience
  • Strong trouble-shooting skills, including the abilities analyse and to think creatively and independently
  • High degree of manual immunofluorescent and immunohistochemical staining (multiplexing and optimization) and microscopy experience
  • Histology experience including embedding, microtomy and tinctorial staining
  • Experience with in-situ hybridisation staining and trouble-shooting (specifically RNAScope) both manual and automated
  • Experience in service provision, user support or development of research projects.
  • Strong organisational, IT and administration skills
  • Strong written and verbal communication skills
  • Ability and evidence of prioritising work and working independently
  • Experience training others in lab techniques
  • Effective team player with a flexible and cooperative approach to working with others.
  • Open and interactive with line manager, laboratory colleagues and collaborators.
  • An understanding of the importance of equality in the work place, and of maintaining the highest standards of scientific integrity and reproducibility.

Desirable:

  • PhD in a relevant discipline
  • Given talks at internal and external meetings                                                  
  • Experience in Image acquisition, digitisation and analysis
  • Expertise in rodent dissections (including Embryos)
  • Experience working with a diverse team
  • Experience training others
  • Use of automated IHC staining platforms

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.