This is a full-time, fixed term (4 year) position on Crick terms and conditions of employment.
The research group
We are seeking a talented postdoctoral researcher to help uncover the biological processes that lead to inflammatory bowel disease (IBD) and determine how these are affected by genetic variation. The successful applicant will join the Genetic Mechanisms of Disease lab, led by James Lee, at the Francis Crick Institute - a pioneering biomedical research institute dedicated to innovation and science.
The Lee lab studies the pathogenesis of immune-mediated and inflammatory diseases using genetics, genomics, molecular biology, and CRISPR-based approaches (all in primary immune cells). Our goal is not only to resolve the pathways involved, but to identify therapeutic opportunities that could lead to better treatments.
Genetic studies in Crohn’s disease and ulcerative colitis (collectively termed inflammatory bowel disease or IBD) have been incredibly successful, but the pathogenic mechanisms at disease-associated loci remain largely unknown.
We have developed a series of complementary methods to study the underlying biology, including scalable methods to functionally resolve causal variants, CRISPR-based approaches to establish the physiological role(s) of associated loci, and in vitro and in vivo assays of immune cell function to determine the pathological consequences. The successful applicant will use these – and other methods – to help resolve disease mechanisms at uncharacterised genetic loci that have biological activity in subsets of primary CD4 T cells. There will be a possibility of extending this work into other cell-types, and/or identifying small molecule modulators of any identified pathways.
For more information, see https://www.crick.ac.uk/research/labs/james-lee or for an example of related work, see Bourges et al. Resolving mechanisms of immune‐mediated disease in primary CD4 T cells. EMBO Molecular Medicine 2020. https://www.embopress.org/doi/full/10.15252/emmm.202012112
Informal enquiries are welcome, and should be directed to James Lee (firstname.lastname@example.org).
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
- PhD, or in the final stages of PhD completion, in a relevant biomedical science (including but not limited to: genetics, immunology, molecular biology, cell biology)
- Experience in molecular biology, including cloning
- Experience of mammalian cell culture
- Knowledge of immunology and/or experience in methods to assess immune function
- Willingness to employ, optimise and develop new techniques
- Ability to work independently and as part of a small team, including providing support for PhD students where necessary
- Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
- Evidence of data presentation at scientific meetings
- Excellent organisational and communication skills
- Experience in flow cytometry
- Experience with CRISPR-Cas9
- Experience in bioinformatics (preferably R/Bioconductor)
Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.