Postdoctoral Training Fellow x2

Postdoctoral Training Fellows are expected to lead their own projects and collaborate within the lab and externally. The ability to work in a team is essential.

Key information

Job reference
R421
Salary
Competitive with benefits, subject to skills and experience.
Application close date
31 October 2021, 23:59 GMT
Hours per week
36 (full time)
Number of positions
2
Posted 04 October 2021
Background texture taken from the lab imagery.

This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment.

         

The research group

We are a highly interactive, international group of postdoctoral scientists, clinical and non-clinical PhD students leading research into cancer metabolism. We look forward to welcoming new members who share our passion to understand cancer metabolism and to identify vulnerabilities in these pathways as targets for therapy.

https://intranet.crick.ac.uk/teams/vousden-lab

Project summary

Our lab has made major contributions to understanding how nutrient availability, metabolism and ROS regulation impact cancer initiation and progression. We have recently been awarded an ERC grant to study the metabolic mechanisms underpinning obesity-driven pancreatic cancer by defining the metabolic crosstalk between the adipocytes in the tumour environment and the tumour cells themselves. Using metabolomic profiling, isotope tracing analysis and mouse models, the project aims to understand how adipocytes, the modulation of oxidative stress and formate metabolism affect adipocyte-cancer interactions. For this project we are seeking postdoctoral fellows who will make use of a wide range of techniques, including metabolomics, cell biology and mouse studies. We need dedicated, ambitious, creative and collaborative scientists with previous experience in cancer cell biology, mouse models of obesity or pancreas cancer and cancer cell or systemic metabolism. Postdoctoral Training Fellows are expected to be self-motivated and independently drive this own research projects, while also contributing to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential

  • PhD in the area of cancer biology or metabolism or in the final stages of PhD submission
  • High degree of proficiency in at least one of the following areas
  • Metabolic pathways – expertise in lipid metabolism is a bonus
  • Systemic metabolism in mice
  • Cancer models and the analysis of tumour/host interactions
  • Technical metabolomic analysis
  • Expertise in cell and molecular biology
  • Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
  • Evidence of data presentation at scientific meetings
  • Experience of experimental design
  • Ability to work independently and also capable of interacting within a group