Postdoctoral Training Fellow

Postdoctoral Training Fellows are expected to lead their own projects and collaborate within the lab and externally. The ability to work in a team is essential.

Key information

Job reference
R452
Salary
From £38,300 depending on experience
Application close date
01 December 2021, 23:59 GMT
Hours per week
36 (full time)
Posted 08 November 2021
Background texture taken from the lab imagery.

Reports to:

Vassilis Pachnis

Contact term:

This is a full-time, fixed term (4 Years) position on Crick terms and conditions of employment.

Project summary

Dr Pachnis’ laboratory focuses on understanding the development of the nervous system and its role in the regulation of tissue and organ homeostasis. To address these questions the lab focuses on the enteric nervous system (ENS) and strives to understand the genetic and molecular mechanisms that control the development of the enteric neuron and glia lineages and how they integrate into the tissue circuitry that regulates intestinal homeostasis and host defense. Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/labs/vassilis-pachnis

Research techniques used in the laboratory include: Genetic modification and phenotypic characterisation of model experimental organisms, primary cell culture, bulk and single cell transcriptomic and chromatin analysis, computational and mathematical modelling.

The Research Group

The research aims to understand the role of gene expression and chromatin organisation in the specification and differentiation of ENS lineages. In this project, some of the specific aims could include but not be limited to:

  • Transcriptomic analysis of enteric neurons and glia at different developmental stages
  • Characterisation of chromatin accessibility changes of ENS lineages at different developmental stages
  • Analysis of gene regulatory networks that regulate ENS lineage development

Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential

  • PhD in developmental biology/neurobiology or in the final stages of PhD submission
  • Good knowledge and experience in techniques of molecular and cell biology, including light/confocal microscopy
  • Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
  • Evidence of data presentation at scientific meetings
  • Experience of experimental design
  • Ability to work independently and also capable of interacting within a group

Desirable

  • Experience in research with model organisms
  • Experience in transcriptomic analysis and chromatin characterisation
  • Experience in bioinformatics and computational biology