Bioinformatics Officer – Bioinformatics Core Facility

The position of Bioinformatics Officer within the Bioinformatics Core Facility provides primarily computational and bioinformatics expertise to support high throughput post-genomic technologies (next generation sequencers), within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the Core group.

Key information

Job reference
R518
Salary
Salary between £38,000-£45,000 per annum with benefits, subject to skills & experience
Application close date
10 December 2021, 23:59 GMT
Hours per week
36 (full time)
Posted 11 November 2021
Background texture taken from the lab imagery.

Reports to: Head of Bioinformatics Core Facility

This is a full-time, fixed-term (3 years) position on Crick Terms and Conditions of Employment.

Salary between £38,000-£45,000 per annum inclusive, subject to skills & experience

                                               

OVERVIEW

The position of Bioinformatics Officer within the Bioinformatics Core Facility will provide primarily computational and bioinformatics expertise to support high throughput post-genomic technologies (next generation sequencers), within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the Core group. In addition this role will provide support in bioinformatics where needed.

This position will be part of an already existing Core team of 14 providing bioinformatics expertise to the Crick scientists.

PROJECT SUMMARY

In this role you will be asked to provide bioinformatics and data analysis support to projects run by the Downward lab at the Francis Crick Institute. Using a variety of programming, statistical and data analysis techniques you will analyse data produced by the latest high throughput genomic technologies. Typical analysis steps will cycle through quality assessment, results generation, biological interpretation and ultimately named publication. During this process you will be expected to work closely with other members of the bioinformatics team, the Downward lab and the advanced sequencing team. As well as the analysis of data from more established applications there will be the opportunity to analyse data from more bespoke applications requiring the development of new pipelines and SOFTWARE.

The Downward lab study the effect of oncogenic RAS signalling on the tumour microenvironment in lung cancer. With the recent clinical approval of sotorasib, the first drug targeting KRASG12C, we reached an important milestone in the treatment of this cancer. The Downward lab developed two orthotopic mouse models --immune cold and immune hot-- to test the effect KRASG12C inhibitors on the cancer cells and on the tumour immune microenvironment (TIME) in vivo. In collaboration with the pharmaceutical company BMS, they generated CITE-Seq and imaging mass cytometry (IMC) data of treated and untreated tumours. Your main project will consist of analysing the CITE-Seq data and interact with other members of the team to correlate the finding with the observations made using IMC. You will work directly with a postdoc in the Downward lab and with an experienced bioinformatician in the Bioinformatics Core Facility.

KEY RESPONSIBILITIES

These include but not limited to;

  • Provide expert analysis of high-throughput genomic data, using a wide range of biological resources and bioinformatic methods.
  • Develop methodologies and techniques to address analysis issues and implement software and data resources in relation to these technologies.
  • Evaluate and provide software, databases, protocols and methods to aid in the analysis of genomic and genetics experiments from academic and commercial sources.
  • Provide consultation and communication in data analysis, data mining, statistics, genomics and other areas of bioinformatics, to Crick scientists.
  • Collaborate in developing the Core with other members of the Bioinformatics group, Crick scientists and other bioinformatics research groups within the Crick.
  • Continue professional development through maintaining awareness of developments in the wider bioinformatics and research communities.
  • Manage the running of our bioinformatics analysis pipelines (Nextflow) and monitor their use so we get results that we can disseminate and interpret to Crick scientist.
  • Participate and contribute to Crick meetings, workshops and seminars.
  • Publish where appropriate.

KEY EXPERIENCE AND COMPETENCIES

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

Knowledge

  • Higher degree in a relevant subject with an extensive analytical component e.g. bioinformatics, statistics, molecular biology or mathematics.
  • An understanding of programming, particularly with regard to big data, data visualisation and data-mining techniques within a genomic or genetical environment.
  • Familiarity with the application of statistical techniques to biological data.
  • A basic knowledge of molecular biology, genetics, model organisms and possibly cancer biology and immunology.
  • A broad comprehension of high throughput genomic technologies.
  • A working knowledge of how to design and build data resources, and their use.

Experience

  • Considerable experience in bioinformatics or related biological field.
  • Demonstrable experience of programming in a higher level language (R/C/C++/Perl/Python).
  • Demonstrable experience of NGS analysis methodologies and protocols.
  • Experience of interaction with investigators on scientific projects and working in a collaborative environment.

Skills and Competencies

  • Proven ability in programming.
  • Works with minimal supervision, organising and prioritising own workload.
  • Excellent communication skills within a research environment, building highly effective working relationships with team and customers.
  • Excellent scientific analysis skills.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.