Postdoctoral Fellow – State-dependent Neural Processing Laboratory & Applied Biotechnology Laboratory

Postdoctoral Training Fellows are expected to lead their own projects and collaborate within the lab and externally. The ability to work in a team is essential.

Key information

Job reference
R370
Salary
From £38,300 per annum, subject to skills and experience
Application close date
11 January 2022, 23:59 GMT
Hours per week
36 (full time)
Posted 19 November 2021
Background texture taken from the lab imagery.

Reports to: Johannes Kohl, Group Leader & Sam Rodriques, Group Leader

This is a full-time, fixed term (48 months) position on Crick terms and conditions of employment.

           

Summary

This position is for a postdoctoral fellow in the State-dependent Neural Processing Laboratory led by Johannes (Jonny) Kohl. In close collaboration with Sam Rodriques’ Applied Biotechnology Laboratory, the postholder will seek to develop next-generation viral tracing approaches to  interrogate the form and function of neural circuits. Suitable candidates should have a background in areas such as molecular, cellular or systems neuroscience, cellular/molecular biology or biotechnology.

Project summary

A postdoctoral position is available in Johannes Kohl’s State-dependent Neural Processing Laboratory at the Francis Crick Institute, in close collaboration with Sam Rodriques’ Applied Biotechnology Laboratory. The Kohl lab uses a multidisciplinary approach, ranging from in vivo calcium imaging, electrophysiology, behavioural profiling and viral circuit tracing to investigate the neuronal and circuit mechanisms by which physiological states alter information processing in the brain. The Applied Biotechnology Laboratory works at the interface between academic bioengineering and biotechnology entrepreneurship. Its mission is to develop biotechnologies that address major unmet needs in biology and medicine and to put them into every laboratory or every clinic in the world.

The program will be co-supervised by Jonny Kohl and Sam Rodriques who have highly complementary expertise in circuit neuroscience and biotechnology, respectively. The candidate will have the opportunity to contribute new, high-impact biotechnologies, while applying those technologies to answer fundamental questions in circuit neuroscience.

The goal of this project is to combine new, cell-type-specific viral vectors developed by the Rodriques lab with a new approach to viral circuit tracing developed by the Kohl lab in order to address major open questions in neuroscience. The successful candidate will develop novel viral reagents in collaboration with the Crick’s newly established Viral Vector Core, test these both in cell culture and in mouse models, and use these novel reagents to address open questions in circuit neuroscience.

Key responsibilities

These include but are not limited to:

  • Independently conducting experiments and analyzing results related to the program of research.
  • Writing grant applications and giving pitches to philanthropists to support the program of research. The postdoctoral fellow will not ordinarily need to obtain money for his/her own research projects, but will be expected to participate in raising money for future research projects.
  • Forming and pursuing collaborations with other academic labs.
  • Maintaining high-quality lab notes and maintaining the central lab inventory.
  • Reporting on a regular basis to the leaders of the State-dependent Neural Processing Laboratory and of the Applied Biotechnology Laboratory
  • Presenting results at lab meetings and at international conferences.
  • Writing up results and publishing papers in major, internationally recognized journals.
  • Assisting in training graduate students and other members of the laboratory.

In addition, as necessary or desired, the postholder will have the opportunity to consult for external companies on topics related to his/her research, and to pitch his or her ideas to investors and to participate in the technology transfer process.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential:

Qualifications, experience and competencies:

  • PhD in neuroscience, bioengineering, cellular / molecular biology or similar
  • At least 3 years of experience in fields such as circuit or cellular neuroscience, molecular biology (cloning, cell culture), bioengineering and animal research
  • A demonstrated ability to generate and pursue independent research ideas
  • Strong skills in organising and thorough record-keeping
  • Strong collaborative ability and teamwork experience
  • Strong communication and presentation skills

Desirable:

  • Experience in rodent models
  • A track record of publishing high-impact papers