This is a full-time, fixed term position until May 2023 on Crick Terms & Conditions of Employment
Altered metabolism is one of the cancer hallmarks and offers promising opportunities for designing new therapies. We are using mouse models and metabolomics approaches to evaluate the requirement of metabolic pathways for tumours carrying specific genetic lesions. The complexity of metabolic interactions between a tumour and the rest of the body, flexibility of metabolism and inter and intra tumour heterogeneity present challenges that require the development of new approaches in order to understand how to target the altered metabolism of tumours efficiently and specifically.
Our lab uses various metabolomics approaches to evaluate the activity of metabolic pathways in vivo including mass spectrometry imaging. Ultimately we are aiming to determine how metabolic changes are aligned with genetic profiles of tumours in time and space and how these interactions determine tumours’ metabolic vulnerabilities. The post holder will be a part of the team of researchers in Mariia Yuneva’s lab and will also interact with researchers from National Physical Laboratory and Imperial college London.
The successful candidate is likely to be an energetic, focused, and productive individual with a desire to work in a congenial, dynamic, and collaborative research environment. Good organisational, analytical, and communication skills are essential.
A successful candidate will use multi-omics dataset analysis to evaluate the relationship between metabolism, genetic lesions and cellular composition in mouse models, patient cancer samples and ex vivo models derived from them.
Specific objectives will include, but not be limited to:
- Perform metabolomics analysis of tissue samples, including sample preparation and data analysis.
- Design experiments in collaboration with wet-lab scientists and integrate experimental data including transcriptomics, proteomics, metabolomics (including stable isotope based in vitro and in vivo metabolomics) and mass spectrometry imaging.
- Regularly attend and participate in scientific meetings in Mariia Yuneva’s lab, several larger interest groups and forums at the Crick as well as with collaborators.
- Write and contribute to the preparation of scientific manuscripts, reports, presentations and records of experimental plans and results
- Supervise and provide technical advice to other team members when appropriate
The Francis Crick institute is an entirely new institute with a distinctive vision of how biomedical research is conducted. It is one of the most significant projects in UK biomedical science for a generation. The institute’s labs have an international reputation for cutting edge research into basic biology and are committed to training the next generation of research scientists.
On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick moved to a single new, purpose built research centre in St. Pancras which houses some 1,500 staff.
The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:
- PhD or equivalent in bioinformatics or computational biology or similar.
- Substantial experience in metabolomics analysis including stable isotope labelling.
- Experience in integrating multi-dimensional omics data.
- Good programming skills (e.g. Java, C++, perl), experience with R/BioConductor.
- Proven track-record of research (e.g. publication record).
- Strong written and oral communication skills.
- Ability to prioritise and manage own time. Ability to multi-task and integrate the demands of different activities in parallel.
- Ability to work independently and also capable of interacting within a group.
- Metabolic modelling and flux analysis for mammalian systems.
- Experience in building databases and bioinformatics pipelines.
- Wet-lab experience.
A post holder is expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.