Postdoctoral Training Fellow - Host-Pathogen Interactions in Cryptosporidiosis Lab

Postdoctoral Training Fellows are expected to lead their own projects and collaborate within the lab and externally. The ability to work in a team is essential.

Key information

Job reference
R620
Salary
From £38,300, subject to skills and experience
Hours per week
36 (full time)
Posted 11 February 2022
Background texture taken from the lab imagery.

Reporting to: Adam Sateriale

Contact term: This is a full-time, fixed-term (4yr) position on Crick terms and conditions of employment.

Closing date and time: Open ended, advert will be taken down when roles are filled.

Summary

Cryptosporidium, or ‘crypto’, is an intracellular parasite that invades intestinal epithelial cells and causes a severe diarrhoeal disease in humans. Acute infections can be deadly, but even mild cases are linked to growth stunting and impaired cognitive development in children. Despite this significant impact on global health, very little is known about how the crypto parasite establishes infection and evades the host immune response. Some of the questions that make up the core research in our lab:

How does the parasite evade detection and suppress host immunity? What parasite factor determine virulence? How do they function?    

How does the immune system recognize and respond to a crypto infection? What host factors predispose one to a severe infection? How do they function?

To answer these questions, we use a variety of cutting-edge approaches: parasite and host genetic engineering via CRISPR, genomics and transcriptomics, expansion and super-resolution microscopy, stem-cell based cell culture (intestinal organoids), flow cytometry, and more. We also work with animal models of infection to study virulence and pathogenesis.

Although we are primarily a parasitology lab, non-parasitologists are strongly encouraged to apply; we strive for scientific and cultural diversity that drives innovative research. As part of an ERC funded grant, we have several postdoctoral positions available for motivated scientists. Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential. For more information or questions please contact adam.sateriale@crick.ac.uk.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

  • PhD in Biological Sciences (or in final stages)
  • Evidence of independent and original contribution to research
  • Ability to manage project timelines
  • Ability to work collaboratively in small teams
  • Ability to communicate and present data at meetings and conferences
  • Expertise in one or more of the following is highly desirable: bioinformatics, epithelial cell biology, mucosal immunology

Equality, Diversity & Inclusion

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion