Laboratory Research Officer - Briscoe Lab

Role descriptor: Works as part of a team to provide scientific and/or technical support to staff, students and more senior colleagues. Works on straightforward tasks within well-established routines and procedures under regular, direct supervision and sometimes while undergoing formal training.
Deadline for applications has passed.

Key information

Job reference
From £25,750 per annum, subject to skills and experience.
Applications closed
01 August 2022, 23:59 BST
Hours per week
36 (full time)
Posted 18 July 2022
Background texture taken from the lab imagery.

Laboratory Research Officer– Briscoe Lab

Reports to: Principal Group Leader

This is a full-time, fixed term (9 month) position on Crick terms and conditions of employment.



A Laboratory Research Officer position is available in the Briscoe lab. The lab aims to understand the molecular and cellular mechanisms that underpin the development of the vertebrate neural tube. In this tissue, secreted molecules form extracellular gradients that regulate the expression of a set of genes, notably transcription factors, which control the identity and proliferation of neural progenitors thereby governing pattern formation and tissue growth. Using a range of molecular, imaging and modelling approaches that combine single cell resolution dynamic assays of morphogen signalling, cell fate specification, gene regulation and growth the lab investigates how signalling is perceived and interpreted by cells to control gene expression and cell behaviour. They develop novel tools and approaches to obtain a comprehensive view of neural tube development and to analyze the interdependence between different aspects of pattern formation. For the experimental studies a range of models including mouse and chick embryos and mouse and human embryonic stem cells are used.

Project summary

The lab is looking for a highly motivated, proactive and enthusiastic researcher to study the molecular mechanisms of cis regulatory element function during spinal cord development.

The project will involve designing and performing experiments using mouse embryonic stem cells differentiation models and novel proteomic approaches. The Laboratory Research Officers will work in collaboration with other lab members and the ability to work in a team is essential.

Key responsibilities

These include but are not limited to:

  • Designing and performing experiments
  • Record keeping
  • Data interpretation

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, open and collegial, in addition to the following:


Qualifications, experience and competencies:

The candidate should be open-minded, creative, energetic and bring strong expertise and experimental background in at least one of the fields of chromatin biochemistry, embryonic stem cell differentiation systems, or genetic engineering of mammalian cells including molecular cloning.

Basic knowledge of molecular cell biology (cell culture, basic molecular biology concepts and techniques) is essential.

Preference will be given to candidates with knowledge and experience in developmental biology, light microscopy and flow cytometry.

  • BSc or equivalent in biochemistry or molecular biology or equivalent experience
  • Good knowledge and experience in eukaryotic gene regulation, including experience in molecular cloning
  • Experience in biochemistry (protein quantification, affinity purification)
  • Experience in mammalian cell culture
  • Evidence of data presentation in research setting or in publications
  • Experience of experimental design, project management and record keeping
  • Ability to work independently and also capable of collaborating within a group


Qualifications, experience and competencies:

  • Experience with mouse embryonic stem cell culture and differentiation systems
  • Experience with flow cytometry and/or fluorescence light microscopy