Senior Laboratory Research Scientist

Applies an in-depth knowledge of research, technical or other scientific practices, methods and procedures gained through either experience and/or formal academic qualifications and applies this knowledge to provide a range of specialist activities. Senior Laboratory Research Scientist is the level at which careers in this functional family typically stabilise.
Deadline for applications has passed.

Key information

Job reference
R815
Salary
From £36,500, subject to skills and experience
Applications closed
07 September 2022, 23:59 BST
Hours per week
36 (full time)
Number of positions
2
Posted 11 August 2022
Background texture taken from the lab imagery.

Reports to:

  • Emma Nye, Experimental Histopathology Lead

Contact term:

  • There is one full-time, permanent position on Crick terms and conditions of employment.

Organisation and Objectives

The Francis Crick institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and Kings College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute is a world-leading centre of biomedical research and innovation, promoting connections between researchers from different disciplines, and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute has the scale, vision, and expertise to tackle the most challenging scientific questions underpinning health and disease. It has a strong national role —training scientists and developing ideas for public good.

Experimental Histopathology (EHP) is a Science Technology Platform (STP) within the Crick, providing a comprehensive and interactive centre for the histology-based analysis of experimental tissues and human bio resources/clinical trials, with the aim of relating experimental models to the pathology of human disease. Crick scientists are encouraged to collaborate with, and work in the EHP STP, and training Crick scientists is an essential activity of the laboratory.

Position description and person specification

The post-holder will work as part the EHP STP team, providing advice, training, and expertise in a range of techniques to analyse cells and tissues from experimental models and human tissue banks. Their time will be spent in the lab, where they will have responsibility for Immunohistochemical/Immunofluorescent (IHC/IF) staining of a wide variety of experimental tissues; paraffin, frozen and vibratome. This will include manual antibody optimisation, and automated staining on the Leica Bond RX and Ventana Discovery platforms. Other responsibilities will include histological sample preparation, embedding and sectioning FFPE, frozen and vibratome tissues.  The post holder will report to senior staff and the head of the laboratory, Emma Nye, and will interact closely with other laboratory staff, plus post-docs, students, scientists, and technicians from other labs at the Crick, as well as scientific partners of the Crick.

Key responsibilities will include, but not be limited to:

  • Operating as a technical advisor in IHC/IF manual antibody optimisation, mainly for FFPE tissues, and using knowledge to innovate and build on existing methodologies
  • Ensuring that scientific work is carried out accurately and efficiently and by own initiative, as agreed with senior staff and the head of the EHP STP
  • Contributing to the day-to-day operations and performing general histology techniques, plus operation and maintenance of STP equipment, sample accession and preparation, and contributing to the team's collective success
  • Exemplifying and maintaining the standards of the service
  • Liaising with other members of the EHP team; actively supporting and training team members to develop their skills and promote successful project outcomes
  • Interacting with and consulting collaboratively with users of the service, to help plan experiments and provide training, where necessary
  • Assessment of innovative technologies and development of new technologies to expand the capabilities of the STP under guidance of senior EHP staff/STP Lead
  • Communication of lab results on a day-to-day basis, at lab meetings and STP talks, to keep colleagues informed of developments and lab practice
  • Strive for continuous performance improvement and professional development in the fields of histopathology and multiplexed IHC, by attending courses and workshops, presenting work at scientific meetings, and keeping abreast of the relevant literature and developments in the field
  • Ensuring compliance to health and safety regulations. Writing risk assessments and standard operating procedures

For all these tasks, the post holder will liaise with other junior and senior research support staff in the lab and elsewhere in the institute.

Person Specification

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegiate, in addition to the following:

Essential

  • Degree (or equivalent) or extensive relevant experience
  • Evidence of extensive experience/skills in IHC/IF antibody optimisations
  • Extensive Histology experience including embedding, microtomy (FFPE), cryotomy, vibratome sectioning and tinctorial staining
  • Strong trouble-shooting skills, including the ability to analyse and think creatively and independently
  • High degree of self-motivation and ability to work with day-to-day independence, but able to take direction when necessary
  • Ability to multi-task and integrate the demands of different activities in parallel to maintain operation of the laboratory.
  • Excellent communication skills and in giving talks at internal and external meetings
  • High degree of computer literacy
  • Open and interactive with line manager, laboratory colleagues and collaborators.

Desirable

  • Experience in RNAScope staining and ISH
  • Experience using Roche discovery Ultra and Bond RX for IHC
  • Experience in microscopy and image analysis
  • Expertise in rodent dissections (including Embryos)
  • PhD in a relevant discipline
  • Experience in working in an academic environment
  • Experience in working in service provision
  • Practical expertise in multiplex staining and imaging using Leica Bond and Vectra Polaris platforms

Please note all offers of employment are subject to successful security screening and continuous eligibility to work in the UK.