Senior Laboratory Research Scientist
This is a permanent position on Crick Terms and Conditions of Employment
Altered metabolism is one of the cancer hallmarks and offers promising opportunities for designing new therapies. One of the biggest challenges in understanding how to target the altered metabolism of tumours effectively is inter and cross-tumour heterogeneity. Mariia Yuneva’s lab is studying how metabolic changes are aligned with genetic profiles of tumours as well as the mechanisms determining tumour metabolic vulnerabilities. We are employing in vivo models, ex vivo 3D culture, metabolomics and transcriptomics analysis as well as mass spectrometry imaging. We are looking for a very pro-active, enthusiastic and well-organized individual to be involved in samples processing and analysis among other responsibilities. An experience with metabolite extraction, tissue sectioning, immunohistochemistry, tissue culture and animal models of cancer is a plus.
Please visit Yuneva’s lab external website: https://www.crick.ac.uk/research/a-z-researchers/researchers-v-y/mariia-yuneva/ and CRUK Grand Challenge website: http://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/grand-challenge-award/funded-teams-bunch for information.
The Francis Crick institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.
The institute is a world-leading centre of biomedical research and innovation. It promotes connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute has the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It is world-class with a strong national role—training scientists and developing ideas for public good. Opened in November 2015, The Crick is located in a new, purpose built research centre in central London (Brill Place next to St. Pancras International) and houses some 1,250 researchers and 250 support staff.
Specific objectives of the post holder will include, but not be limited to:
- Mouse colony management
- Preparing samples for metabolomics analysis and analysis of mass spectrometry data.
- Tissue sectioning
- Histological analysis, immunohistochemistry and immunofluorescence
- Generation and characterisation of organotypic cultures
- Supporting some aspects of in vivo experiments including tumour model generation, maintenance and monitoring, tissue collection and processing.
- Providing technical support to group staff when required as well as carrying out specific research projects.
- Regularly attending and participating in scientific meetings in Mariia Yuneva’s lab, several larger interest groups and forums at the Crick as well as Consortium meetings.
- Contributing to the preparation of scientific manuscripts, reports and presentations
- Establish, maintain and improve research protocols and records
The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:
- BSc or PhD in Biology, Biochemistry, Molecular Biology or Cell Biology
- Experience in standard biochemistry and molecular biology
- Experience in culture of primary cells and/or cell lines
- Experience in histology and immunohistochemistry
- Experience with animal handling and small animal surgery
- Experience working with GM mice, mouse cancer models and/or patient derived xenografts
- Holder of UK Animal scientific procedures personal license
- Experience generating stably transfected cell lines (transfection and sub-cloning)
- Experience in metabolomics analysis
For any questions relating to this role, please contact Mariia Yuneva, Group Leader via Mariia.Yuneva@crick.ac.uk