Postdoctoral Training Fellow
This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment.
The research group
We are a highly interactive, international group of postdoctoral scientists, clinical and non-clinical PhD students and research scientists. The main focus of our work is to understand cancer metabolism and to identify vulnerabilities in these pathways as targets for therapy.
https://intranet.crick.ac.uk/teams/vousden-lab
Project summary
The work in our laboratory is focused on how nutrient availability and metabolism affect cancer development, and this project will focus on the role of the tumour suppressor protein, p53. Our past work has shed light on various aspects of p53 biology, such as how p53 is regulated and the activity of mutant p53s that are commonly expressed in cancers. Our goal is to understand the mechanistic biology underlying these phenomena and thereby reveal novel vulnerabilities and therapeutic approaches. For this project we are looking for postdoctoral fellows who will expand on our recent studies examining how p53 controls the interplay between cancer cells and the surrounding tumour microenvironment. The successful applicant will use a wide range of techniques, including cell biology, metabolomics and in vivo studies. We need dedicated, ambitious and collaborative scientists with previous experience in cancer cell biology. Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
Essential
- PhD in a relevant area of biology or in the final stages of PhD submission
- Good knowledge and experience in cancer biology
- Technical expertise in cell and molecular biology
- Technical expertise in mouse models
- Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
- Evidence of data presentation at scientific meetings
- Experience of experimental design
- Ability to work independently and also capable of interacting within a group
Desirable
- Knowledge and experience in metabolism
- Knowledge and experience in tumour/host interactions e.g. immune response
