Senior / Laboratory Research Scientist – Biological Inorganic Chemistry Lab
This is a full-time, fixed term (12 months) position on Crick terms and conditions of employment.
This vacancy is for a fixed-term (12 months) Senior/Laboratory Research Scientist (S/LRS) to support the Biological Inorganic Chemistry Laboratory led by Dr Jeannine Hess.
Antibiotics are the cornerstone of our modern healthcare settings allowing the treatment of previously life-threatening bacterial infections. However, with the emergency of pathogenic bacteria resistant to common antibiotics, we are at serious risk of heading towards the pre-antibiotic era. We are looking at new concepts to target essential microbial enzymes, to develop inorganic and organometallic compounds capable of killing Gram-positive and Gram-negative bacteria.
The ideal candidate will have experience in medicinal chemistry, chemical biology and/or inorganic chemistry. The candidate will provide support on a multidisciplinary research project and actively contributes on synthetic aspects as well as on assay development to drive the research project. We nurture a collaborative lab atmosphere with scientific creativity and productivity, complementing our team on the mission towards new therapies against drug-resistant bacteria.
Applications are welcome from candidates with a background in organic chemistry, medicinal chemistry, excellent organisational skills and an interest in the use of fragment-based approaches to identify new therapeutic leads.
The Research Group
We are a synthetic and medicinal chemistry research group and are passionate about working at the forefront of developing new and innovative solutions to combat infectious diseases.
Our research focusses on moving beyond conventional drug discovery programs. We develop and apply target-based and structure-guided approaches (such as Fragment-Based Drug Discovery) and combine it with inorganic/organometallic chemistry to generate tool compounds and drug candidates with new mechanisms of action relying on the interplay of organic moieties and inorganic counterparts.
Most of the projects in the group are centred around the application of new concepts to target essential enzymes to allow the development of rationally designed metal-containing probes and antimicrobial drug candidates. We are particularly interested in understanding the role and mechanism of action of metal-containing molecules in order to tune their activity and potency in disease models. We are eager to leverage the unique features of metal centres such as their redox and/or catalytic activity to design antimicrobial compounds able to trigger metal-specific mechanisms of action under physiological conditions.
We rely extensively on state-of-the-art chemical synthesis and analytical chemistry to generate new, rationally designed compounds. Current techniques utilised in the group range from differential scanning fluorimetry (DSF), ligand-based NMR spectroscopy, isothermal titration calorimetry (ITC) and in-vitro enzymatic assays. This Laboratory Research Scientist (LRS) role would suit a team player who enjoys juggling a multidisciplinary project and building relationships across disciplines.
These include but are not limited to:
- Coordinate and conduct fragment-based and drug discovery approaches at the initial stage of the research project
- Improving established and/or develop new protocols
- Compile preliminary data to validate target essentiality and druggability
- Coordinate collaborative research project and setting up regular meetings to discuss progress
Experience and Competencies
- BSc or MSc degree or equivalent level of experience in inorganic/organometallic chemistry, medicinal chemistry, organic chemistry or drug discovery
- Knowledge of different biophysical techniques for compound validation
- Eagerness to learn new techniques and contribute to multi-disciplinary research at the interface of chemistry and structural and molecular biology
- Strong skills in organising and recording experiments
- Ability to communicate and present data
- Strong collaborative ability and teamwork experience
- Experience in fragment-based drug discovery
- Experience in assay development and structural biology
- Experience in relevant software tools such as PyMOL and Prism
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.
- If you are interested in applying for this role, please apply via our website.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
- If you require a visa to work in the UK we will help support your application should you be successful