Postdoctoral Training Fellow
Reports to: Dimitrios Anastasiou, Group Leader
This is a fixed-term (3 year), full-time position on Crick terms and conditions of employment.
There is no closing date: position will be filled when a suitable candidate has been identified.
We seek a highly motivated and ambitious postdoc to develop novel technologies for shedding light on new biology and shaping drug development for the future.
The project will make use of reactive fragment libraries, which consist of low molecular weight fragments with reactive functional warheads that allow irreversible capture of target proteins. The role of this postdoctoral training fellow will be to characterise the effects of the fragments on cell signalling and metabolism, on a global scale, using a combination of high throughput analytical and genetic methods. The postdoc will then use this information, in collaboration with experts in computational biology and chemoproteomics, to identify and further study novel regulators of cell signalling and metabolism, and how these processes synergize to support functions of normal and cancer cells.
The post is part of a project funded by an EPSRC Prosperity Partnership award that brings together multiple research groups at the Crick and GSK to pioneer use of reactive fragments and high-content screening technologies in cellular disease model systems (https://www.crick.ac.uk/news/2021-04-02_francis-crick-institute-and-gsk-to-pioneer-reactive-fragment-screening-in-drug-discovery). The postdoc will thus be part of a dynamic, multi-disciplinary team working in an integrated academia–industry setting.
The Research Group
The role will be based in the laboratories of Dr. Michael Howell (Crick High Throughput Screening Facility) and Dr. Dimitrios Anastasiou, (Cancer Metabolism Laboratory). Dr. Howell’s laboratory uses state-of-the-art high throughput approaches to study a broad range of biological problems. Dr. Anastasiou’s research investigates the fundamental mechanisms that regulate healthy cellular and whole-body metabolism and how disruption of these mechanisms contributes to cancer development and metabolic liver disease. To this end, the lab uses a multidisciplinary approach that includes mouse models of liver disease and cancer, metabolomics, stable isotope-labelled tracers to measure metabolic activities in vivo, computational modelling and protein biochemistry. The postdoc will also have the opportunity to interact with the group of Dr. Caroline Hill who are performing analogous screens that focus on the roles of TGF-β family signalling pathways in normal physiology and in cancer.
Postdocs are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
- PhD (or in the final stages of submission) in biochemistry, cell/cancer biology, physiology or related discipline
- Excellent knowledge and experience in cancer biology and/or metabolism
- Technical expertise in tissue culture, imaging, molecular biology, and gene perturbation
- A track record of high productivity in the laboratory, supported by publications in peer-reviewed journals
- Good oral and written communication skills evidenced by data presentation at scientific meetings
- Experience of experimental design and project management
- Ability to work independently and also as part of a team
- Eagerness to work in an interdisciplinary environment at the interface between academia and industry
- Technical expertise in performing high content screens/high content imaging
- Practical experience with studying cellular signalling and metabolism
- Experience in integrating large amounts of data from multiple platforms
- Knowledge of chemical biology