Senior/Laboratory Research Scientist

Applies an in-depth knowledge of research, technical or other scientific practices, methods and procedures gained through either experience and/or formal academic qualifications and applies this knowledge to provide a range of specialist activities. Senior Laboratory Research Scientist is the level at which careers in this functional family typically stabilise.
Deadline for applications has passed.

Key information

Job reference
R1053
Salary
From £29,150 - £42,250 subject to skills and experience.
Applications closed
30 January 2023, 23:59 GMT
Hours per week
36 (full time)
Posted 16 January 2023
Background texture taken from the lab imagery.

Senior/Laboratory Research Scientist  

Reporting to: Dr Florencia Iacaruso, Group Leader

Contract term: This is a full-time, fixed term (two years) position on Crick terms and conditions of employment.

This role is advertised as a Senior/Laboratory Research Scientist meaning the correct level will be assigned to the successful candidate.

LRS: Applies specific technical or practical skills and has a well-developed working knowledge of technical or scientific practices and procedures acquired through on-the-job, vocational or academic training. Work will involve the application of skills and knowledge to provide a range of technical support activities.

SLRS: Applies an in-depth knowledge of research, technical or other scientific practices, methods and procedures gained through either experience and/or formal academic qualifications and applies this knowledge to provide a range of specialist activities.

Summary

The Iacaruso lab is seeking an experienced and enthusiastic Senior/Laboratory Research Scientist, who can help with the management, curation, and analysis of large-scale experimental datasets. This key role is to provide support in terms of data organisation and analysis to the members of the team. This entails the maintenance of the databases and code repositories for the lab, as well as organising data structures for applying state of the art machine learning and statistical data analysis algorithms. The successful candidate would have experience in dealing with large-scale multidimensional datasets, ideally in the context of bioinformatics and/or neuroscience. Extensive programming skills (in Python and MATLAB) and best practices of code documentation and organisation are expected. Knowledge of computational methods and experimental approaches in neuroscience is desired.

The Role

The role of a Senior/Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes.  Typical activities include:

• Collaborating with other lab members on/Assisting other lab members with/ research projects.

• Providing experimental or technical support to other lab members.

• Providing technical expertise/ input for the development, refinement and troubleshooting of relevant /novel methodologies. [‘novel’ SLRS only]

• Undertaking own research project, designing, and executing experiments /with strategic direction from the group leader. [SLRS only]

• Managing long-term investigations and collaborations with other researchers. [SLRS only]

• Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.

• Writing up findings for publication /and completing revisions. [SLRS only]

• Training and supervising other lab members in key techniques and protocols, lab operations, and equipment use.

The Research Group

Dr Iacaruso’s laboratory studies general principles of neural circuit organization that govern sensory perception and behaviour. The laboratory aims to delineate how the functional organization of neuronal networks gives rise to multisensory representations and sensory-motor transformations. Current research is focused on circuitry in cortical and subcortical regions, such as the visual cortex and the superior colliculus.

Details of research projects currently being undertaken can be seen at:  https://www.crick.ac.uk/research/labs/flor-iacaruso/areas-of-interest. Research techniques used in the Dr Iacaruso’s laboratory include in vivo two-photon microscopy, Neuropixels recordings in head-fixed and freely moving mice, optogenetics and in vitro circuit mapping.

Key responsibilities

These include but are not limited to:

  • Manage, maintain and update the data repository for the lab.
  • Develop an understanding of the analysis objectives set by the team.
  • Provide data analysis to support members of the team.
  • Carry out analysis of high-dimensional datasets including Neurophysiological recordings using a standard set of software packages as well as bespoke computational methods.
  • Interpret results in the context of the analysis objectives.
  • Communicate results to the group members via project meetings and analysis reports.
  • Participate and contribute to group meetings, workshops and seminars.

Experience and Competencies

The successful applicant will have experience with the analysis of multi-dimensional and multi-scale data. Highly motivated candidates with a background in computational neuroscience, bioinformatics, statistics, mathematics, computer science or physics are encouraged to apply.

The successful candidate will need to be an independent thinker, motivated to do science and able to work in a highly collaborative environment. Applicants will be selected based on how well they demonstrate that they meet the essential and desirable criteria for this particular role.

The post holder should embody and demonstrate our core Crick values:

Bold; Open; Collegial

Essential

  • A degree in a relevant subject with an extensive analytical component, e.g. bioinformatics, statistics, mathematics, computer science or physics, or equivalent experience
  • Considerable experience in relevant programming languages (MATLAB, Python).
  • Experience in applying data science to project work in a collaborative research environment, ideally in a biological context.
  • Experience in applying statistical models for the analysis of large, complex, and multimodal datasets e.g. neuronal recordings.
  • Excellent problem-solving skills.
  • The ability to work independently on tasks and organise and prioritise workload within a project management framework.
  • Strong written and oral communication skills, with the ability to present complex information effectively.

Desirable

  • Familiarity with the application of bio-statistical techniques to biological data.
  • Experience building workflows and pipelines for analytical problems.
  • Expertise in bioinformatics processes and applications.
  • Experience with common data standards for neurophysiology such as Neurodata Without Borders (NWB) or DataJoint.
  • Experience in the study of sensory processing.
  • Experience in behavioural neuroscience. 

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

  • If you are interested in applying for this role, please apply via Workday.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom