Laboratory Research Scientist - Systems Chemical Biology of Infection and Resistance

Applies specific technical or practical skills and has a well-developed working knowledge of technical or scientific practices and procedures acquired through on-the-job, vocational or academic training. Work will involve the application of skills and knowledge to provide a range of technical support activities.

Key information

Job reference
R1061
Salary
From £29,150, with benefits, subject to skills and experience.
Application close date
07 February 2023, 23:59 GMT
Hours per week
36 (full time)
Posted 24 January 2023
Background texture taken from the lab imagery.

Laboratory Research Scientist - Systems Chemical Biology of Infection and Resistance 

Contract term: This is a full-time, fixed term (2 years) position on Crick terms and conditions of employment.

Salary for this Role: From £29,150, with benefits, subject to skills and experience.

The Role

The role of a Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes. Typical activities include:

  • Collaborating with other lab members on research projects.

  • Providing experimental or technical support to other lab members.

  • Providing technical expertise for the development, refinement and troubleshooting of relevant methodologies.

  • Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.

  • Organisation and management of the laboratory, including maintaining laboratory databases, ordering of laboratory supplies, monitoring budgets, and routine maintenance of laboratory equipment. 

  • Training and supervising other lab members in key techniques and protocols, lab operations, and equipment use.

  • Liaising with Science Operations and attending key quadrant meetings.

  • Writing risk assessments and SOPs and providing safety guidance to lab members.

The Research Group

The Systems Chemical Biology of Infection and Resistance Lab studies how pathogenic bacteria survive and infect, using chemical biology and genetic tools to define new gene targets and their chemical inhibitors. Ultimately, we aim to enable antimicrobial therapies which exploit key weaknesses in the ability of pathogenic bacteria to evolve resistance to antibiotics. Working at the interface of genetics, chemical biology, and machine learning, we discover and use small molecules to precisely disrupt the cellular machinery of pathogenic bacteria and study consequent effects on survival, infection, and evolution.

We primarily study Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), and Klebsiella pneumoniae, the cause of many antibiotic resistant hospital- and community-acquired infections. We use small molecules to complement genetic studies because they are easily applied to disparate cell types and species, precisely perturb specific functions of multifunctional gene products, and directly bridge the gap between implication of genes in disease and new therapeutics.

The Systems Chemical Biology of Infection and Resistance Lab opened in January 2021 and is supported by Crick core funding, the BBSRC, and the UKRI Horizon Europe Guarantee. We work with cutting edge Scientific Technology Platforms including Advanced Sequencing, Flow Cytometry, Proteomics, Metabolomics, and High-Throughput Screening. The lab currently has nine members with a balanced mix of postdocs and PhD students, with a Senior Laboratory Research Scientist. Over the next two years, we expect to expand to twelve people.

Key responsibilities

These include but are not limited to:

  • Liaising with Scientific Technology Platforms

  • Optimising phenotypic assays in Mycobacterium tuberculosis

  • Assisting deployment of high-throughput compound screens to discover new antimicrobials

  • Analysis of high-throughput screening data

Experience and Competencies

The post holder should embody and demonstrate our core Crick values: Bold; Open; Collegial.

Essential

  • BSc (or equivalent) in chemistry, chemical biology, molecular biology, microbiology, systems biology, biological engineering, or related field

  • Ability to work independently and as part of a team

  • Ability to work towards agreed-upon goals

  • Strong oral and written communication skills

  • Excellent organisational skills

  • Enthusiasm and initiative to develop new skills and new methods

  • Motivation to use interdisciplinary and quantitative approaches to answer scientific questions

Desirable

  • Understanding of next-generation sequencing platforms

  • Familiarity with cell-based high-throughput screening assays

  • Experience with Python or R

  • Ability to prioritise and manage own time

  • Ability to communicate and present data