Job title: Postdoctoral Fellow – S. Gamblin Lab
Reporting to: Steve Gamblin, Director Research Infrastructure and Group Leader
Contract term: This is a full-time, fixed term 4 year position on Crick terms and conditions of employment.
The Research Group
The Gamblin laboratory applies structural biology and biophysics techniques to determine the molecular mechanisms of major macromolecular complexes implicated in disease. Details of research projects currently being undertaken can be seen on our website at: https://www.crick.ac.uk/research/labs/steve-gamblin. Research techniques used in the laboratory include Cryo-Electron Microscopy, X-Ray crystallography, biophysical characterisation of protein-protein and protein-nucleic acid interactions and enzyme kinetics.
The aims of this project include an investigation of the of the molecular mechanisms of viral surface protein and host cell receptor interactions that ultimately lead to viral fusion and infection. In this project, some of the specific aims could include but not be limited to:
Structural characterisation of viral surface proteins
Cryo EM using the facilities at the Francis Crick Institute
Biophysical characterisation of the host cell surface protein interactions.
Characterisation of intermediate protein conformational states.
Postdoctoral Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.
We wish to recruit a Postdoctoral Fellow to join the Gamblin team to work on a project focused on determining the molecular mechanisms of viral infectivity. The aim is to investigate the conformational dynamics of fusion with the host cell membrane mediated by viral surface protein and the molecular factors that regulate the efficiency of this process. The successful candidate will principally use methods in structural biology enzymology and biophysics combined with the advantages of working in the multi-disciplinary environment of the Francis Crick Laboratories
Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
PhD in a structural biology or related field or in the final stages of PhD submission
Good knowledge and experience in protein biochemistry and enzymology
Technical expertise in recombinant protein production
Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
Evidence of data presentation at scientific meetings
Experience of experimental design
Experience in research with multi-protein complexes
Experience in the design and analysis of enzyme assays
Experience in protein binding studies
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc programme that prepares scientists for leadership roles in science.
If you are interested in applying for this role, please apply via our website.
All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
If you require a visa to work in the UK we will help support your application should you be successful