Deadline for applications has passed.

Key information

Job reference
From £31,675 per annum plus benefits, subject to skills and experience
Applications closed
19 December 2023, 12:00 GMT
Hours per week
36 (full time)
Posted 27 November 2023
Background texture taken from the lab imagery.

Job title:  Laboratory Research Scientist (LRS)


Reporting to:  Francesca Ester Morreale, Group Leader


Contract term:  This is a full-time, fixed term 1 year position on Crick terms and conditions of employment


Closing date and time: the position will remain open until suitable candidates are found


The Role

We are seeking a talented and dedicated Laboratory Research Scientist (LRS) to join Dr Francesca Ester Morreale’s newly established Targeted Protein Degradation & Antibiotic Research laboratory at the Francis Crick Institute. The role is laboratory-based and requires previous experience with recombinant protein expression and purification, as well as molecular cloning.


Candidates interested in this role should apply via our website and include a cover letter highlighting how their experience and skills match the job description and indicating:

  • their earliest potential start date

  • their research interests and how they align with the work of our laboratory


Please submit your application at the earliest availability, the position will remain open until suitable candidates are found. Informal enquiries can be directly addressed to


The Research Group

Dr Morreale’s research group aims to establish targeted protein degradation technology in pathogenic bacteria, integrating structural biology, chemical biology and microbiology. Targeted degradation of bacterial proteins holds the potential of significantly expanding the number of tractable antimicrobial targets and represents a novel approach to antibiotics discovery.


The laboratory provides an excellent learning environment, where the successful candidate will interact closely with medicinal chemists, structural biologists and microbiologists, and will have access to a range of in-house state-of-the art equipment and expert support.


Key responsibilities

The successful candidate will be involved in a current project aimed at developing small molecule degraders of mycobacterial proteins and will be responsible for characterising their mechanism of action in vitro.


Key areas of responsibility will include, but are not limited to:

  • Protein expression and purification

  • Molecular cloning

  • Setting up biochemical assays

  • Measuring protein-ligand binding affinities


Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, open, collegial, in addition to the following:

  • BSc (Hons) degree or equivalent in a relevant subject

  • Previous experience with recombinant protein expression and purification in E. coli 

  • Previous experience with molecular biology techniques

  • Ability to work independently and also to interact within a group

  • Enthusiasm, creativity, critical thinking and problem-solving skills

  • Excellent communication skills


About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

  • If you are interested in applying for this role, please apply via our website.

  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

  • If you require a visa to work in the UK we will help support your application should you be successful.