Job title: Senior Laboratory Research Scientist
Reporting to: Mark Skehel, Head of Proteomics, Proteomics STP
Contact term: This is a full-time, fixed term (2 year) position on Crick terms and conditions of employment.
As part of a Crick-GSK LinkLabs collaboration, we are seeking an enthusiastic senior laboratory research scientist (SLRS) to be based in the Proteomics - Scientific Technology Platform (STP) at the Francis Crick Institute. The SLRS will develop and implement cutting-edge mass spectrometry methods with a focus on the development of high-throughput chemoproteomic workflows to enable profiling of reactive covalent fragment interactions in cells and lysates. This exciting collaborative project will provide career development in an integrated academia-industry setting that combines the skills and expertise of scientists in the Crick with those in GSK.
The successful candidate will be part of a dynamic, multi-disciplinary team working to combine mass spectrometry, next generation chemistry and phenotypic screens with machine learning technologies to accelerate the selection of new drug targets. You will take initiative in project design and interact closely with colleagues working on the project. It is anticipated that you will bring on board extensive knowledge of label free quantitative proteomic approaches, applying the methodology to discovery and translational research. This is a multi-faceted project with a strongly interdisciplinary focus. The project will be co-supervised by Crick and GSK scientists and has considerable scope to evolve.
Proteomics STP and Crick-GSK LinkLabs
This Crick–GSK LinkLabs collaboration is aimed at developing a Systems Chemical Biology platform to enable simultaneous identification of disease-associated proteins and functional chemical probes. The project is funded by an EPSRC Prosperity Partnership award that brings together multiple research groups at the Crick and GSK to pioneer reactive fragments and high-content screening technologies in cells (https://www.crick.ac.uk/news/2021-04-02_francis-crick-institute-and-gsk-to-pioneer-reactive-fragment-screening-in-drug-discovery and https://www.crick.ac.uk/news/2019-02-08_benefits-of-moving-in-together ).
Key experience and competencies
The successful candidate can expect excellent career development in biological mass spectrometry as well as the opportunity to collaborate with and learn from GSK and Crick experts working in other disciplines; particularly, computational chemistry, structural biology, cell biology, biochemistry and medicinal chemistry.
The post holder should embody and demonstrate our core Crick values: bold; open; and collegial, in addition to the following:
Qualifications, experience and competencies:
A PhD or equivalent experience gained through working in a mass spectrometry laboratory, including basic and advanced proteomic sample handling and processing protocols, and familiarity with instrument maintenance requirements.
Direct experience with either the Thermo Scientific Orbitrap Tribrid platform or the Bruker timsTOF Ultra/Pro2.
Detailed understanding of proteomics related bioinformatics and associated software packages such as Proteome Discoverer, PEAKS, Mascot, Scaffold, MaxQuant, Spectronaut, DIA-NN and Skyline.
Experience of independently organising and running projects.
Excellent communication, record keeping, time management and problem-solving skills
Ability to work confidently and independently, approaching research problems with initiative and flexibility.
Qualifications, experience and competencies:
Ability to digest and clearly present highly technical information to other scientists, including experts in the field.
Experience in applying analytical approaches to interrogate complex datasets and generate hypotheses.
A track record of high productivity in mass spectrometry/proteomics, supported by publications in peer-reviewed journals.
Experience with proteome level post-translational modification analyses (e.g., phosphorylation, ubiquitination, acetylation/methylation).
Experience with developing, optimizing and applying next-generation proteomics and mass spectrometry methods such as DIA, DDA, label free profiling, TMT, PRM etc.
Basic understanding of biostatistics and computational programming.
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.
If you are interested in applying for this role, please apply via our website.
All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
If you require a visa to work in the UK we will help support your application should you be successful