Given the many unknowns about cancer, Gerard understands why these battle metaphors have emerged and become embedded into our language. But he thinks that terminology can detract from our understanding of what cancer actually is. “When we use emotive language like this, it implies that the cancer, or tumour, is actively competing with us. This suggests that it has a purpose, a thought process, what we would call ‘agency’,” he says.
“I think this misconception is rooted in the pervasive notion that evolution is heading in a particular direction. The giraffe didn’t grow its neck to be able to eat the fronds and leaves at the top of the tree. Giraffes weren’t aiming to make that change. It happened because of natural selection. Natural variation in neck length gave some giraffes a food advantage and this was passed on through their offspring. Evolution looks like it’s heading in a particular direction because we only see the winners. We don’t see the many losers that died out.
“And the same goes for cancer. We know that cancers are caused by changes in the genes that control whether and when a cell divides and spreads or not. Such changes are happening all the time in your body, but in most cases the errors in the DNA are so catastrophic that these would-be cancer cells simply can’t survive. They die off, or are dealt with by our immune system, and don’t go on to form a tumour. So we only see the genetic changes that are the so-called ‘winners’ – the cancer cells that survive, which unfortunately are not good news for the patient.”
This is a topic that has interested the Crick’s resident philosopher too. James DiFrisco is a group leader who works on theoretical and philosophical issues in biology. He says: “Systems like cancer can appear goal-oriented. For example, the cancer ‘wants’ to spread. But this doesn’t mean that the tumour has true agency, or that it’s ‘aiming’ to act in a specific way.”
James has recently published a discussion on the topic of agency in biology and how natural selection shapes complex systems, making it appear as though a biological process is acting with purpose. “Humans are predisposed to attribute agency, or purpose, when dealing with complex or poorly understood phenomena,” he says. “And in the context of a cancer diagnosis, people have a strong need to make sense of their condition, so may naturally see purpose and intention where it doesn’t exist. Our consideration of the language that we use needs to balance clarity, scientific accuracy and sensitivity to the psychological needs of people with cancer.”