Scientists at the National Institute for Medical Research
(now part of the Francis Crick Institute) have found a
link that vegetables such as broccoli, brussel sprouts and cabbage
contain nutrients which play an important role in maintaining
healthy skin and a healthy gut. The nutrients in cruciferous
vegetables - such as broccoli - help to ensure a good balance of
bacteria in the skin and intestine (known as epithelial barriers).
The findings have been published in Cell.
Epithelial barriers are home to controlled numbers and types of
microorganisms. In the intestine many of these help with digestion
and provide essential metabolic compounds. Disturbances to this
delicate equilibrium can give rise to disease such as inflammatory
bowel disease. Although many microorganisms are beneficial,
the body needs protection against attack from microorganisms that
cause disease.
Underneath the epithelial barrier there is a network of immune
cells, predominantly consisting of specialised intraepithelial
lymphocytes (IELs). These are important as a first line of defence
but they also help to organise and regulate the bacteria in the
epithelial barrier and help to repair wounds in the skin or gut.
These immune cells populate these sites before birth in preparation
for subsequent colonisation with microorganisms.
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Marc Veldhoen, working in Gitta Stockinger's lab in NIMR's
Division of Molecular Immunology, has shown that compounds in
cruciferous vegetables are important in maintaining the numbers of
immune cells protecting the intestine and skin. The compound -
known as aryl hydrocarbon receptor (AhR) - was regulated by
nutrients found in the vegetables. Gitta Stockinger said: "This
research provides a direct molecular link between eating greens as
part of a balanced diet and the health of a person's skin and gut.
It demonstrates why eating your greens is good for you."
Marc Veldhoen moved to the Babraham Institute in 2010, but most
of the work described was carried out at NIMR. This year he has
been awarded an ERC Starting Independent Researcher Grant from the
European Research Council to continue this research at
Babraham.
Original article: Exogenous stimuli maintain intraepithelial
lymphocytes via aryl hydrocarbon receptor activation.
Ying Li, Silvia Innocentin, David R. Withers, Natalie A.
Roberts, Alec R. Gallagher, Elena F. Grigorieva, Christoph Wilhelm
and Marc Veldhoen (2011).
Cell, Epub ahead of print. Publisher
abstract.