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Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). 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Research (1)PLOS ONE (1)RSC Advances: an international journal to further the chemical sciences (1)Science advances (1)Science Translational Medicine (1)Seminars in Immunology (1)Trends in Biochemical Sciences (1)Virus Research (1) Facet Journal Publications Displaying 41 - 60 of 91Last updated : 28 March 2024 02:21 Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein Authors (9)Antoni WrobelDonald BentonSaira Hussain Ruth Harvey Stephen R MartinChloe RoustanPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 21 October 2020 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyScientific computingFull details Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option Authors (9)Kevin NgJan Attig William BollandGeorge YoungJack MajorAntoni WrobelSteve GamblinAndreas WackGeorge Kassiotis Nature Genetics Published 1 December 2020 Crick labs/ facilitiesAndreas WackJonathan StoyeGeorge KassiotisSteve GamblinScientific computingFlow CytometryCell ServicesAdvanced SequencingFull details Hemagglutinin traits determine transmission of avian A/H10N7 influenza virus between mammals Authors (20) Sander HerfstJie Zhang Mathilde Richard Ryan McBride Pascal Lexmond Theo M Bestebroer[...] Erhard van der Vries Albert DME Osterhaus James C Paulson John J Skehel Ron AM Fouchier Cell Host and Microbe Published 7 October 2020 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion Authors (8)Donald BentonAntoni Wrobel Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Published 10 December 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Authors (8)Antoni WrobelDonald Benton Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Structural & Molecular Biology Published 1 August 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details Hemagglutinin structure and activities Authors (6)Steve Gamblin Sébastien G Vachieri Xiaoli XiongJie Zhang Stephen R Martin John J Skehel Cold Spring Harbor Perspectives in Medicine Published 1 October 2021 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Structural transitions in influenza haemagglutinin at membrane fusion pH Authors (4)Donald BentonSteve GamblinPeter Rosenthal John J Skehel Nature Published 2 July 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Sudden death associated with a novel H401Q PRKAG2 mutation Authors (7) Maria Helena Albernaz Siqueira Kinulpe Honorato-Sampaio Glauber Monteiro DiasJon Wilson Arash Yavari Geraldo Brasileiro Filho Eduardo Back Sternick Europace Published 1 August 2020 Crick labsSteve GamblinFull details G-tract RNA removes Polycomb repressive complex 2 from genes Authors (14) Manuel Beltran Manuel TavaresNeil Justin Garima Khandelwal John Ambrose Benjamin M Foster[...] Javier Herrero Till BartkeSteve GamblinJon Wilson Richard G Jenner Nature Structural and Molecular Biology Published 1 October 2019 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details A key to unlock chromatin Authors (2)Steve GamblinJon Wilson Nature Published 19 September 2019 Crick labsSteve GamblinFull details Professor Derek Burke 1930-2019 Authors (1) J Skehel Microbiology Today Published 6 August 2019 Crick labsSteve GamblinFull details Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion Authors (11) Thomas P PeacockDonald Benton Jean-Remy Sadeyen Pengxiang Chang Joshua E Sealy Juliet E Bryant Stephen R Martin Holly SheltonJohn MccauleyWendy Barclay Munir Iqbal Emerging Microbes & Infections Published 15 January 2019 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details Influenza hemagglutinin membrane anchor Authors (13)Donald BentonAndrea NansLesley CalderJack Turner Ursula Neu Yi Pu Lin[...] Davide Corti Antonio LanzavecchiaSteve GamblinPeter Rosenthal John J Skehel Proceedings of the National Academy of Sciences of the United States of America Published 17 September 2018 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyElectron MicroscopyFull details Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis Authors (5)Madushi WanaguruDavid BarryDonald BentonNicola O'ReillyKate Bishop PLOS Pathogens Published 15 June 2018 Crick labs/ facilitiesSteve GamblinKate BishopLight MicroscopyStructural BiologyFull details The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites Authors (7) Anshumali Mittal Fruzsina HoborYing Zhang Stephen R MartinSteve Gamblin Andres RamosJon Wilson Nucleic Acids Research Published 20 April 2018 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Production and crystallization of full-length human AMP-activated protein kinase (α1β1γ1) Authors (3)Julia Hubbard Bing XiaoJon Wilson Methods in Molecular Biology Published 27 February 2018 Crick labsSteve GamblinFull details Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells Authors (10) Robin Willows Matthew J Sanders Bing Xiao Bhakti R Patel Stephen R Martin Jon ReadJon WilsonJulia HubbardSteve Gamblin David Carling Biochemical Journal Published 22 August 2017 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics Authors (11) Thomas P PeacockDonald Benton Joe James Jean-Remy Sadeyen Pengxiang Chang Joshua E Sealy Juliet E Bryant Stephen R Martin Holly SheltonWendy Barclay Munir Iqbal Journal of Virology Published 26 June 2017 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Pagination 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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein Authors (9)Antoni WrobelDonald BentonSaira Hussain Ruth Harvey Stephen R MartinChloe RoustanPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 21 October 2020 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyScientific computingFull details
Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option Authors (9)Kevin NgJan Attig William BollandGeorge YoungJack MajorAntoni WrobelSteve GamblinAndreas WackGeorge Kassiotis Nature Genetics Published 1 December 2020 Crick labs/ facilitiesAndreas WackJonathan StoyeGeorge KassiotisSteve GamblinScientific computingFlow CytometryCell ServicesAdvanced SequencingFull details
Hemagglutinin traits determine transmission of avian A/H10N7 influenza virus between mammals Authors (20) Sander HerfstJie Zhang Mathilde Richard Ryan McBride Pascal Lexmond Theo M Bestebroer[...] Erhard van der Vries Albert DME Osterhaus James C Paulson John J Skehel Ron AM Fouchier Cell Host and Microbe Published 7 October 2020 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion Authors (8)Donald BentonAntoni Wrobel Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Published 10 December 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Authors (8)Antoni WrobelDonald Benton Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Structural & Molecular Biology Published 1 August 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
Hemagglutinin structure and activities Authors (6)Steve Gamblin Sébastien G Vachieri Xiaoli XiongJie Zhang Stephen R Martin John J Skehel Cold Spring Harbor Perspectives in Medicine Published 1 October 2021 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Structural transitions in influenza haemagglutinin at membrane fusion pH Authors (4)Donald BentonSteve GamblinPeter Rosenthal John J Skehel Nature Published 2 July 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Sudden death associated with a novel H401Q PRKAG2 mutation Authors (7) Maria Helena Albernaz Siqueira Kinulpe Honorato-Sampaio Glauber Monteiro DiasJon Wilson Arash Yavari Geraldo Brasileiro Filho Eduardo Back Sternick Europace Published 1 August 2020 Crick labsSteve GamblinFull details
G-tract RNA removes Polycomb repressive complex 2 from genes Authors (14) Manuel Beltran Manuel TavaresNeil Justin Garima Khandelwal John Ambrose Benjamin M Foster[...] Javier Herrero Till BartkeSteve GamblinJon Wilson Richard G Jenner Nature Structural and Molecular Biology Published 1 October 2019 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
A key to unlock chromatin Authors (2)Steve GamblinJon Wilson Nature Published 19 September 2019 Crick labsSteve GamblinFull details
Professor Derek Burke 1930-2019 Authors (1) J Skehel Microbiology Today Published 6 August 2019 Crick labsSteve GamblinFull details
Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion Authors (11) Thomas P PeacockDonald Benton Jean-Remy Sadeyen Pengxiang Chang Joshua E Sealy Juliet E Bryant Stephen R Martin Holly SheltonJohn MccauleyWendy Barclay Munir Iqbal Emerging Microbes & Infections Published 15 January 2019 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details
Influenza hemagglutinin membrane anchor Authors (13)Donald BentonAndrea NansLesley CalderJack Turner Ursula Neu Yi Pu Lin[...] Davide Corti Antonio LanzavecchiaSteve GamblinPeter Rosenthal John J Skehel Proceedings of the National Academy of Sciences of the United States of America Published 17 September 2018 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyElectron MicroscopyFull details
Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis Authors (5)Madushi WanaguruDavid BarryDonald BentonNicola O'ReillyKate Bishop PLOS Pathogens Published 15 June 2018 Crick labs/ facilitiesSteve GamblinKate BishopLight MicroscopyStructural BiologyFull details
The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites Authors (7) Anshumali Mittal Fruzsina HoborYing Zhang Stephen R MartinSteve Gamblin Andres RamosJon Wilson Nucleic Acids Research Published 20 April 2018 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Production and crystallization of full-length human AMP-activated protein kinase (α1β1γ1) Authors (3)Julia Hubbard Bing XiaoJon Wilson Methods in Molecular Biology Published 27 February 2018 Crick labsSteve GamblinFull details
Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells Authors (10) Robin Willows Matthew J Sanders Bing Xiao Bhakti R Patel Stephen R Martin Jon ReadJon WilsonJulia HubbardSteve Gamblin David Carling Biochemical Journal Published 22 August 2017 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics Authors (11) Thomas P PeacockDonald Benton Joe James Jean-Remy Sadeyen Pengxiang Chang Joshua E Sealy Juliet E Bryant Stephen R Martin Holly SheltonWendy Barclay Munir Iqbal Journal of Virology Published 26 June 2017 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details