Alessandro Costa: Publications

  • Douglas, ME; Abid Ali, F; Costa, A and Diffley, JFX (2018)
    The mechanism of eukaryotic CMG helicase activation.
    Nature 555, 265-268 PubMed abstract
  • Abid Ali, F; Douglas, ME; Locke, J; Pye, VE; Nans, A; Diffley, JFX and Costa, A (2017)
    Cryo-EM structure of a licensed DNA replication origin.
    Nature Communications 8, 2241 PubMed abstract
  • Ballandras-Colas, A; Maskell, DP; Serrao, E; Locke, J; Swuec, P; Jónsson, SR; Kotecha, A; Cook, NJ; Pye, VE; Taylor, IA; Andrésdóttir, V; Engelman, AN; Costa, A and Cherepanov, P (2017)
    A supramolecular assembly mediates lentiviral DNA integration.
    Science 355, 93-95 PubMed abstract
  • Eickhoff, P and Costa, A (2017)
    Escorting client proteins to the Hsp90 molecular chaperone.
    Structure 25, 964-966 PubMed abstract
  • Frigola, J; He, J; Kinkelin, K; Pye, VE; Renault, L; Douglas, ME; Remus, D; Cherepanov, P; Costa, A and Diffley, JFX (2017)
    Cdt1 stabilizes an open MCM ring for helicase loading.
    Nature Communications 8, 15720 PubMed abstract
  • Miller, TC and Costa, A (2017)
    The architecture and function of the chromatin replication machinery.
    Current Opinion in Structural Biology 47, 9-16 PubMed abstract
  • Swuec, P and Costa, A (2017)
    DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines?
    Biophysical Chemistry 225, 15-19 PubMed abstract
  • Swuec, P; Renault, L; Borg, A; Shah, F; Murphy, VJ; van Twest, S; Snijders, AP; Deans, AJ and Costa, A (2017)
    The FA core complex contains a homo-dimeric catalytic module for the symmetric mono-ubiquitination of FANCI-FANCD2.
    Cell Reports 18, 611-623 PubMed abstract
  • van Twest, S; Murphy, VJ; Hodson, C; Tan, W; Swuec, P; O'Rourke, JJ; Heierhorst, J; Crismani, W and Deans, AJ (2017)
    Mechanism of ubiquitination and deubiquitination in the Fanconi anemia pathway.
    Molecular Cell 65, 247-259 PubMed abstract
  • Wilson, MD and Costa, A (2017)
    Cryo-electron microscopy of chromatin biology.
    Acta Crystallographica. Section D, Structural Biology 73, 541-548 PubMed abstract
  • Zhou, JC; Janska, A; Goswami, P; Renault, L; Abid Ali, F; Kotecha, A; Diffley, JFX and Costa, A (2017)
    CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.
    Proceedings of the National Academy of Sciences of the United States of America 114, 4141-4146 PubMed abstract
  • Abid Ali, F and Costa, A (2016)
    The MCM helicase motor of the eukaryotic replisome.
    Journal of Molecular Biology 428, 1822-1832 PubMed abstract
  • Abid Ali, F; Renault, L; Gannon, J; Gahlon, HL; Kotecha, A; Zhou, JC; Rueda, D and Costa, A (2016)
    Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.
    Nature Communications 7, 10708 PubMed abstract
  • Pellegrini, L and Costa, A (2016)
    New insights into the mechanism of DNA duplication by the eukaryotic replisome.
    Trends in Biochemical Sciences 41, 859-871 PubMed abstract
  • Samora, CP; Saksouk, J; Goswami, P; Wade, BO; Singleton, MR; Bates, PA; Lengronne, A; Costa, A and Uhlmann, F (2016)
    Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome.
    Molecular Cell 63, 371-384 PubMed abstract
  • Chao, WCH; Murayama, Y; Muñoz, S; Costa, A; Uhlmann, F and Singleton, MR (2015)
    Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader.
    Cell Reports 12, 719-725 PubMed abstract
  • Maskell, DP; Renault, L; Serrao, E; Lesbats, P; Matadeen, R; Hare, S; Lindemann, D; Engelman, AN; Costa, A and Cherepanov, P (2015)
    Structural basis for retroviral integration into nucleosomes.
    Nature 523, 366-369 PubMed abstract
  • Petojevic, T; Pesavento, JJ; Costa, A; Liang, J; Wang, Z; Berger, JM and Botchan, MR (2015)
    Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.
    Proceedings of the National Academy of Sciences of the United States of America 112, E249-E258 PubMed abstract
  • Pike, ACW; Gomathinayagam, S; Swuec, P; Berti, M; Zhang, Y; Schnecke, C; Marino, F; von Delft, F; Renault, L; Costa, A; Gileadi, O and Vindigni, A (2015)
    Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures.
    Proceedings of the National Academy of Sciences of the United States of America 112, 4286-4291 PubMed abstract
  • Costa, A; Renault, L; Swuec, P; Petojevic, T; Pesavento, JJ; Ilves, I; MacLellan-Gibson, K; Fleck, RA; Botchan, MR and Berger, JM (2014)
    DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.
    eLife 3, e03273 PubMed abstract
  • Simon, AC; Zhou, JC; Perera, RL; van Deursen, F; Evrin, C; Ivanova, ME; Kilkenny, ML; Renault, L; Kjaer, S; Matak-Vinković, D; Labib, K; Costa, A and Pellegrini, L (2014)
    A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.
    Nature 510, 293-297 PubMed abstract
  • Swuec, P and Costa, A (2014)
    Molecular mechanism of double Holliday junction dissolution.
    Cell & Bioscience 4, 36 PubMed abstract
  • Zhou, JC and Costa, A (2014)
    Preparing to unwind.
    eLife 3, e02618 PubMed abstract
  • Aze, A; Zhou, JC; Costa, A and Costanzo, V (2013)
    DNA replication and homologous recombination factors: acting together to maintain genome stability.
    Chromosoma 122, 401-413 PubMed abstract
  • Costa, A; Hood, IV and Berger, JM (2013)
    Mechanisms for initiating cellular DNA replication.
    Annual Review of Biochemistry 82, 25-54 PubMed abstract
  • Coulthard, R; Deans, AJ; Swuec, P; Bowles, M; Costa, A; West, SC and McDonald, NQ (2013)
    Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
    Structure 21, 1648-1658 PubMed abstract
  • Lyubimov, AY; Costa, A; Bleichert, F; Botchan, MR and Berger, JM (2012)
    ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote.
    Proceedings of the National Academy of Sciences of the United States of America 109, 11999-12004 PubMed abstract
  • Costa, A; Ilves, I; Tamberg, N; Petojevic, T; Nogales, E; Botchan, MR and Berger, JM (2011)
    The structural basis for MCM2-7 helicase activation by GINS and Cdc45.
    Nature Structural & Molecular Biology 18, 471-477 PubMed abstract
  • Dueber, EC; Costa, A; Corn, JE; Bell, SD and Berger, JM (2011)
    Molecular determinants of origin discrimination by Orc1 initiators in archaea.
    Nucleic Acids Research 39, 3621-3631 PubMed abstract

[Page last updated 1 Jun 2018]

Alessandro Costa

Alessandro Costa
+44 (0)20 379 61812

  • Qualifications and history
  • 2007 PhD, Imperial College London, UK
  • 2007 Postdoctoral fellow, University of Oxford, UK
  • 2009 EMBO Postdoctoral fellow, University of California Berkeley, USA
  • 2012 Establish lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK