Dominique Bonnet: Publications

  • Abarrategi, A; Foster, K; Hamilton, A; Mian, SA; Passaro, D; Gribben, J; Mufti, G and Bonnet, D (2017)
    Versatile humanized niche model enables study of normal and malignant human hematopoiesis.
    Journal of Clinical Investigation 127, 543-548 PubMed abstract
  • Bonnet, D (2017)
    Acute myeloid leukemia including favorable-risk group samples engraft in NSG mice: just be patient.
    Haematologica 102, 805-806 PubMed abstract
  • Bonnet, D (2017)
    Remodelling of mesenchymal stromal niche by acute myeloid leukemia.
    Annals of Hematology 96, S17-S18
  • Das, A; Rouault-Pierre, K; Kamdar, S; Gomez-Tourino, I; Wood, K; Donaldson, I; Mein, CA; Bonnet, D; Hayday, AC and Gibbons, DL (2017)
    Adaptive from innate: Human IFN-γ+CD4+ T cells can arise directly from CXCL8-producing recent thymic emigrants in babies and adults.
    Journal of Immunology 199, 1696-1705 PubMed abstract
  • Di Tullio, A; Passaro, D; Rouault-Pierre, K; Purewal, S and Bonnet, D (2017)
    Nuclear factor erythroid 2 regulates human HSC self-renewal and T cell differentiation by preventing NOTCH1 activation.
    Stem Cell Reports 9, 5-11 PubMed abstract
  • Duarte, D; Hawkins, ED; Akinduro, O; Ang, H; De Filippo, K; Haltalli, M; Ruivo, N; Weber, TS; Khorshed, R; Pirillo, C; Ramasamy, S; Purton, LE; Duffy, K; Adams, RH; Carlin, LM and Lo Celso, C (2017)
    Bone marrow ecological collapse in acute myeloid leukemia is mediated by remodeling of endosteal vessels.
    Haematologica 102, 360, Abstract no. E875
  • Helft, J; Anjos-Afonso, F; van der Veen, AG; Chakravarty, P; Bonnet, D and Reis e Sousa, C (2017)
    Dendritic cell lineage potential in human early hematopoietic progenitors.
    Cell Reports 20, 529-537 PubMed abstract
  • Passaro, D; Abarrategi, A; Foster, K; Ariza-McNaughton, L and Bonnet, D (2017)
    Bioengineering of humanized bone marrow microenvironments in mouse and their visualization by live imaging.
    Journal of Visualized Experiments e55914 PubMed abstract
  • Passaro, D; Di Tullio, A; Abarrategi, A; Rouault-Pierre, K; Foster, K; Ariza-McNaughton, L; Chakravarty, P; Bhaw, L; Diana, G; Lassailly, F; Gribben, J and Bonnet, D (2017)
    Acute myeloid leukemia alters the permeability of the bone marrow vascular microenvironment, fostering disease progression and drug resistance.
    Haematologica 102, 78, Abstract no. P264
  • Passaro, D; Di Tullio, A; Abarrategi, A; Rouault-Pierre, K; Foster, K; Ariza-McNaughton, L; Montaner, B; Chakravarty, P; Bhaw, L; Diana, G; Lassailly, F; Gribben, J and Bonnet, D (2017)
    Increased vascular permeability in the bone marrow microenvironment contributes to disease progression and drug response in acute myeloid leukemia.
    Cancer Cell 32, 324-341 e326 PubMed abstract
  • Rak, J; Foster, K; Potrzebowska, K; Safaee Talkhoncheh, M; Miharada, N; Komorowska, K; Torngren, T; Kvist, A; Borg, Å; Svensson, L; Bonnet, D and Larsson, J (2017)
    Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.
    Blood 129, 950-958 PubMed abstract
  • Rouault-Pierre, K; Mian, S; Goulard, M; Abarrategi, A; Di Tullio, A; Smith, A; Mohamedali, A; Best, S; Nloga, AM; Kulasekararaj, A; Ades, L; Chomienne, C; Fenaux, P; Dosquet, C; Mufti, GJ and Bonnet, D (2017)
    Preclinical modeling of myelodysplastic syndromes.
    Haematologica 102, 260, Abstract no. P657
  • Rouault-Pierre, K; Mian, SA; Goulard, M; Abarrategi, A; Tullio, AD; Smith, AE; Mohamedali, A; Best, S; Nloga, A-M; Kulasekararaj, AG; Ades, L; Chomienne, C; Fenaux, P; Dosquet, C; Mufti, GJ and Bonnet, D (2017)
    Preclinical modeling of myelodysplastic syndromes.
    Leukemia [Epub ahead of print] PubMed abstract
  • Rouault-Pierre, K; Smith, AE; Mian, SA; Pizzitola, I; Kulasekararaj, AG; Mufti, GJ and Bonnet, D (2017)
    Myelodysplastic syndrome can propagate from the multipotent progenitor compartment.
    Haematologica 102, e7-e10 PubMed abstract
  • Secklehner, J; Lo Celso, C and Carlin, LM (2017)
    Intravital microscopy in historic and contemporary immunology.
    Immunology and Cell Biology 95, 506-513 PubMed abstract
  • Abarrategi, A; Tornin, J; Martinez-Cruzado, L; Hamilton, A; Martinez-Campos, E; Rodrigo, JP; González, MV; Baldini, N; Garcia-Castro, J and Rodriguez, R (2016)
    Osteosarcoma: cells-of-origin, cancer stem cells, and targeted therapies.
    Stem Cells International 2016, 3631764 PubMed abstract
  • Anjos-Afonso, F; Loizou, JI; Bradburn, A; Kanu, N; Purewal, S; Da Costa, C; Bonnet, D and Behrens, A (2016)
    Perturbed hematopoiesis in mice lacking ATMIN.
    Blood 128, 2017-2021 PubMed abstract
  • Bonnet, D (2016)
    Leukemic stem cell interactions with the microenvironment: friend or foe?
    Human Gene Therapy 27, A17 Abstract INV61
  • Engert, A; Balduini, C; Brand, A; Coiffier, B; Cordonnier, C; Döhner, H; Duyvené de Wit, T; Eichinger, S; Fibbe, W; Green, T; de Haas, F; Iolascon, A; Jaffredo, T; Rodeghiero, F; Salles, G; Schuringa, JJ; André, M; Andre-Schmutz, I; Bacigalupo, A; Bochud, P-Y; den Boer, M; Bonini, C; Camaschella, C; Cant, A; Cappellini, MD; Cazzola, M; Lo Celso, C; Dimopoulos, M; Douay, L; Dzierzak, E; Einsele, H; Ferreri, A; De Franceschi, L; Gaulard, P; Gottgens, B; Greinacher, A; Gresele, P; Gribben, J; de Haan, G; Hansen, J-B; Hochhaus, A; Kadir, R; Kaveri, S; Kouskoff, V; Kühne, T; Kyrle, P; Ljungman, P; Maschmeyer, G; Méndez-Ferrer, S; Milsom, M; Mummery, C; Ossenkoppele, G; Pecci, A; Peyvandi, F; Philipsen, S; Reitsma, P; Ribera, JM; Risitano, A; Rivella, S; Ruf, W; Schroeder, T; Scully, M; Socie, G; Staal, F; Stanworth, S; Stauder, R; Stilgenbauer, S; Tamary, H; Theilgaard-Mönch, K; Thein, SL; Tilly, H; Trneny, M; Vainchenker, W; Vannucchi, AM; Viscoli, C; Vrielink, H; Zaaijer, H; Zanella, A; Zolla, L; Zwaginga, JJ; Aguilar Martinez, P; van den Akker, E; Allard, S; Anagnou, N; Andolfo, I; Andrau, JC; Angelucci, E; Anstee, D; Aurer, I; Avet-Loiseau, H; Aydinok, Y; Bakchoul, T; Balduini, A; Barcellini, W; Baruch, D; Baruchel, A; Bayry, J; Bento, C; van den Berg, A; Bernardi, R; Bianchi, P; Bigas, A; Biondi, A; Bohonek, M; Bonnet, D; Borchmann, P; Borregaard, N; Brækkan, S; van den Brink, M; Brodin, E; Bullinger, L; Buske, C; Butzeck, B; Cammenga, J; Campo, E; Carbone, A; Cervantes, F; Cesaro, S; Charbord, P; Claas, F; Cohen, H; Conard, J; Coppo, P; Vives Corrons, J-L; da Costa, L; Davi, F; Delwel, R; Dianzani, I; Domanović, D; Donnelly, P; DovčDrnovšek, T; Dreyling, M; Du, M-Q; Dufour, C; Durand, C; Efremov, D; Eleftheriou, A; Elion, J; Emonts, M; Engelhardt, M; Ezine, S; Falkenburg, F; Favier, R; Federico, M; Fenaux, P; Fitzgibbon, J; Flygare, J; Foà, R; Forrester, L; Galacteros, F; Garagiola, I; Gardiner, C; Garaud, O; van Geet, C; Geiger, H; Geissler, J; Germing, U; Ghevaert, C; Girelli, D; Godeau, B; Gökbuget, N; Goldschmidt, H; Goodeve, A; Graf, T; Graziadei, G; Griesshammer, M; Gruel, Y; Guilhot, F; von Gunten, S; Gyssens, I; Halter, J; Harrison, C; Harteveld, C; Hellström-Lindberg, E; Hermine, O; Higgs, D; Hillmen, P; Hirsch, H; Hoskin, P; Huls, G; Inati, A; Johnson, P; Kattamis, A; Kiefel, V; Kleanthous, M; Klump, H; Krause, D; Kremer Hovinga, J; Lacaud, G; Lacroix-Desmazes, S; Landman-Parker, J; LeGouill, S; Lenz, G; von Lilienfeld-Toal, M; von Lindern, M; Lopez-Guillermo, A; Lopriore, E; Lozano, M; MacIntyre, E; Makris, M; Mannhalter, C; Martens, J; Mathas, S; Matzdorff, A; Medvinsky, A; Menendez, P; Migliacco, AR; Miharada, K; Mikulska, M; Minard, V; Montalbán, C; de Montalambert, M; Montserrat, E; Morange, PE; Mountford, J; Muckenthaler, M; Müller-Tidow, C; Mumford, A; Nadel, B; Navarro, J-T; el Nemer, W; Noizat-Pirenne, F; O'Mahony, B; Oldenburg, J; Olsson, M; Oostendorp, R; Palumbo, A; Passamonti, F; Patient, R; Peffault de Latour, R; Pflumio, F; Pierelli, L; Piga, A; Pollard, D; Raaijmakers, M; Radford, J; Rambach, R; Koneti Rao, A; Raslova, H; Rebulla, P; Rees, D; Ribrag, V; Rijneveld, A; Rinalducci, S; Robak, T; Roberts, I; Rodrigues, C; Rosendaal, F; Rosenwald, A; Rule, S; Russo, R; Saglio, G; Sanchez, M; Scharf, RE; Schlenke, P; Semple, J; Sierra, J; So-Osman, C; Soria, JM; Stamatopoulos, K; Stagmayr, B; Stunnenberg, H; Swinkels, D; Taborda Barata, JP; Taghon, T; Taher, A; Terpos, E; Thachil, J; Tissot, JD; Touw, I; Toye, A; Trappe, R; Traverse-Glehen, A; Unal, S; Vaulont, S; Viprakasit, V; Vitolo, U; van Wijck, R; Wójtowicz, A; Zeerleder, S and Zieger, B (2016)
    The European Hematology Association Roadmap for European Hematology Research: a consensus document.
    Haematologica 101, 115-208 PubMed abstract
  • Griessinger, E; Anjos-Afonso, F; Vargaftig, J; Taussig, DC; Lassailly, F; Prebet, T; Imbert, V; Nebout, M; Vey, N; Chabannon, C; Filby, A; Bollet-Quivogne, F; Gribben, JG; Peyron, J-F and Bonnet, D (2016)
    Frequency and dynamics of leukemia-initiating cells during short-term ex-vivo culture informs outcomes in acute myeloid leukemia patients.
    Cancer Research 76, 2082-2086 PubMed abstract
  • Hawkins, E; Duarte, D; Akinduro, F; Khorshed, R; Passaro, D; Nowicka, M; Straszkowski, L; Ruivo, N; Scott, M; Rothery, S; Foster, K; Waibel, M; Johnstone, R; Robinson, M; Purton, L; Bonnet, D and Lo Celso, C (2016)
    T cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.
    European Journal of Immunology 46, 329, Abstract no. 3980
  • Hawkins, ED; Duarte, D; Akinduro, O; Khorshed, RA; Passaro, D; Nowicka, M; Straszkowski, L; Scott, MK; Rothery, S; Ruivo, N; Foster, K; Waibel, M; Johnstone, RW; Harrison, SJ; Westerman, DA; Quach, H; Gribben, J; Robinson, MD; Purton, LE; Bonnet, D and Lo Celso, C (2016)
    T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments.
    Nature 538, 518-522 PubMed abstract
  • Iyengar, S; Ariza-McNaughton, L; Clear, A; Taussig, D; Auer, R; Roe, A; Lillington, D; Iqbal, S; Joel, S; Gribben, J and Bonnet, D (2016)
    Characteristics of human primary mantle cell lymphoma engraftment in NSG mice.
    British Journal of Haematology 173, 165-169 PubMed abstract
  • Niavarani, A; Herold, T; Reyal, Y; Sauerland, MC; Buchner, T; Hiddemann, W; Bohlander, SK; Valk, PJM and Bonnet, D (2016)
    A 4-gene expression score associated with high levels of Wilms Tumor-1 (WT1) expression is an adverse prognostic factor in acute myeloid leukaemia.
    British Journal of Haematology 172, 401-411 PubMed abstract
  • Niavarani, A; Horswell, S; Sadri, R and Bonnet, D (2016)
    The Wilms Tumor-1 (WT1) rs2234593 variant is a prognostic factor in normal karyotype acute myeloid leukemia.
    Annals of Hematology 95, 179-190 PubMed abstract
  • Rouault-Pierre, K; Hamilton, A and Bonnet, D (2016)
    Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact.
    Expert Opinion on Biological Therapy 16, 463-476 PubMed abstract
  • Bonnet, D (2015)
    New heterogeneity of the leukemic stem cells.
    In: Targeted Therapy of Acute Myeloid Leukemia. Edited by Andreeff, M.
    New York, Springer 2015. 559-572. (Current Cancer Research).
  • Costello, P; Sargent, M; Maurice, D; Esnault, C; Foster, K; Anjos-Afonso, F and Treisman, R (2015)
    MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development.
    Blood 125, 1244-1255 PubMed abstract
  • Eddison, M; Weber, SJ; Ariza-McNaughton, L; Lewis, J and Daudet, N (2015)
    Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear.
    Frontiers in Cellular Neuroscience 9, 74 PubMed abstract
  • Escobedo-Cousin, M; Jackson, N; Laza-Briviesca, R; Ariza-McNaughton, L; Luevano, M; Derniame, S; Querol, S; Blundell, M; Thrasher, A; Soria, B; Cooper, N; Bonnet, D; Madrigal, A and Saudemont, A (2015)
    Natural killer cells improve hematopoietic stem cell engraftment by increasing stem cell clonogenicity in vitro and in a humanized mouse model.
    PLOS ONE 10, e0138623 PubMed abstract
  • Foster, K; Lassailly, F; Anjos-Afonso, F; Currie, E; Rouault-Pierre, K and Bonnet, D (2015)
    Different motile behaviors of human hematopoietic stem versus progenitor cells at the osteoblastic niche.
    Stem Cell Reports 5, 690-701 PubMed abstract
  • Mian, SA; Rouault-Pierre, K; Smith, AE; Seidl, T; Pizzitola, I; Kizilors, A; Kulasekararaj, AG; Bonnet, D and Mufti, GJ (2015)
    SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.
    Nature Communications 6, 10004 PubMed abstract
  • Miraki-Moud, F; Ghazaly, E; Ariza-McNaughton, L; Hodby, KA; Clear, A; Anjos-Afonso, F; Liapis, K; Grantham, M; Sohrabi, F; Cavenagh, J; Bomalaski, JS; Gribben, JG; Szlosarek, PW; Bonnet, D and Taussig, DC (2015)
    Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.
    Blood 125, 4060-4068 PubMed abstract
  • Niavarani, A; Currie, E; Reyal, Y; Anjos-Afonso, F; Horswell, S; Griessinger, E; Luis Sardina, J and Bonnet, D (2015)
    APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts.
    PLOS ONE 10, e0120089 PubMed abstract
  • Tettamanti, S; Pizzitola, I; Marin, V; Anjos-Afonso, F; Rouault-Pierre, K; Lassailly, F; Spinelli, O; Biondi, A; Bonnet, D and Biagi, E (2015)
    Chimeric antigen receptors for specific targeting of acute myeloid leukemia.
    Annals of Hematology 94, S55-S56
  • Anjos-Afonso, F and Bonnet, D (2014)
    Forgotten gems: Human CD34- hematopoietic stem cells.
    Cell Cycle 13, 503-504 PubMed abstract
  • Griessinger, E; Anjos-Afonso, F; Pizzitola, I; Rouault-Pierre, K; Vargaftig, J; Taussig, D; Gribben, J; Lassailly, F and Bonnet, D (2014)
    A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms.
    Stem Cells Translational Medicine 3, 520-529 PubMed abstract
  • Hamilton, A; Foster, K and Bonnet, D (2014)
    Impairment of AML engraftment to the bone marrow niche following inhibition of TGF-beta signaling.
    Blood 124, Abstract 4372
  • Niavarani, A; Herold, T; Reyal, Y; Currie, E; Horswell, S; Jalali, A; Sauerland, MC; Buchner, T; Hiddemann, W; Bohlander, SK; Malekzadeh, R; Valk, PJM and Bonnet, D (2014)
    A 16-gene signature associated with high levels of Wilms Tumor-1 (WT1) expression is an adverse prognostic factor in acute myeloid leukemia.
    Blood 124, Abstract 1021
  • Pizzitola, I; Anjos-Afonso, F; Rouault-Pierre, K; Lassailly, F; Tettamanti, S; Spinelli, O; Biondi, A; Biagi, E and Bonnet, D (2014)
    Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo.
    Leukemia 28, 1596-1605 PubMed abstract
  • Tettamanti, S; Biondi, A; Biagi, E and Bonnet, D (2014)
    CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
    Oncoimmunology 3, e28835 PubMed abstract
  • Zhao, W; Phinney, DG; Bonnet, D; Dominici, M and Krampera, M (2014)
    Mesenchymal stem cell biodistribution, migration, and homing in vivo.
    Stem Cells International 2014, 292109 PubMed abstract
  • Anjos-Afonso, F; Currie, E; Palmer, HG; Foster, KE; Taussig, DC and Bonnet, D (2013)
    CD34- cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures.
    Cell Stem Cell 13, 161-174 PubMed abstract
  • Jaganathan, BG; Anjos-Afonso, F; Kumar, A and Bonnet, D (2013)
    Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche.
    Journal of Biomedical Science 20, 66 PubMed abstract
  • Kruczynski, A; Pillon, A; Créancier, L; Vandenberghe, I; Gomes, B; Brel, V; Fournier, E; Annereau, JP; Currie, E; Guminski, Y; Bonnet, D; Bailly, C and Guilbaud, N (2013)
    F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity.
    Leukemia 27, 2139-2148 PubMed abstract
  • Lassailly, F; Foster, K; Lopez-Onieva, L; Currie, E and Bonnet, D (2013)
    Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells.
    Blood 122, 1730-1740 PubMed abstract
  • Marlow, R; Honeth, G; Lombardi, S; Cariati, M; Hessey, S; Pipili, A; Mariotti, V; Buchupalli, B; Foster, K; Bonnet, D; Grigoriadis, A; Rameshwar, P; Purushotham, A; Tutt, A and Dontu, G (2013)
    A novel model of dormancy for bone metastatic breast cancer cells.
    Cancer Research 73, 6886-6899 PubMed abstract
  • Miraki-Moud, F; Anjos-Afonso, F; Hodby, KA; Griessinger, E; Rosignoli, G; Lillington, D; Jia, L; Davies, JK; Cavenagh, J; Smith, M; Oakervee, H; Agrawal, S; Gribben, JG; Bonnet, D and Taussig, DC (2013)
    Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation.
    Proceedings of the National Academy of Sciences of the United States of America 110, 13576-13581 PubMed abstract
  • Rouault-Pierre, K; Lopez-Onieva, L; Foster, K; Anjos-Afonso, F; Lamrissi-Garcia, I; Serrano-Sanchez, M; Mitter, R; Ivanovic, Z; de Verneuil, H; Gribben, J; Taussig, D; Rezvani, HR; Mazurier, F and Bonnet, D (2013)
    HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress.
    Cell Stem Cell 13, 549-563 PubMed abstract
  • Taiwo, O; Wilson, GA; Emmett, W; Morris, T; Bonnet, D; Schuster, E; Adejumo, T; Beck, S and Pearce, DJ (2013)
    DNA methylation analysis of murine hematopoietic side population cells during aging.
    Epigenetics 8, 1114-1122 PubMed abstract
  • Tettamanti, S; Marin, V; Pizzitola, I; Magnani, CF; Giordano Attianese, GMP; Cribioli, E; Maltese, F; Galimberti, S; Lopez, AF; Biondi, A; Bonnet, D and Biagi, E (2013)
    Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.
    British Journal of Haematology 161, 389-401 PubMed abstract
  • Valent, P; Bonnet, D; Wöhrer, S; Andreeff, M; Copland, M; Chomienne, C and Eaves, C (2013)
    Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications.
    Cancer Research 73, 1037-1045 PubMed abstract
  • Griessinger, E; Jayasinghe, SN and Bonnet, D (2012)
    Aerodynamically assisted bio-jetting of hematopoietic stem cells.
    Analyst 137, 1329-1333 PubMed abstract
  • Ibrahim, EE; Babaei-Jadidi, R; Saadeddin, A; Spencer-Dene, B; Hossaini, S; Abuzinadah, M; Li, N; Fadhil, W; Ilyas, M; Bonnet, D and Nateri, AS (2012)
    Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.
    Stem Cells 30, 2076-2087 PubMed abstract
  • Jaganathan, BG and Bonnet, D (2012)
    Human mesenchymal stromal cells senesce with exogenous OCT4.
    Cytotherapy 14, 1054-1063 PubMed abstract
  • Kallinikou, K; Anjos-Afonso, F; Blundell, MP; Ings, SJ; Watts, MJ; Thrasher, AJ; Linch, DC; Bonnet, D and Yong, KL (2012)
    Engraftment defect of cytokine-cultured adult human mobilized CD34+ cells is related to reduced adhesion to bone marrow niche elements.
    British Journal of Haematology 158, 778-787 PubMed abstract
  • Patel, S; Zhang, Y; Cassinat, B; Zassadowski, F; Ferré, N; Cuccuini, W; Cayuela, JM; Fenaux, P; Bonnet, D; Chomienne, C and Louache, F (2012)
    Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ-/- mice.
    Leukemia 26, 2432-2435 PubMed abstract
  • Poulin, LF; Reyal, Y; Uronen-Hansson, H; Schraml, BU; Sancho, D; Murphy, KM; Håkansson, UK; Moita, LF; Agace, WW; Bonnet, D and Reis e Sousa, C (2012)
    DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
    Blood 119, 6052-6062 PubMed abstract
  • Quintana-Bustamante, O; Lan-Lan Smith, S; Griessinger, E; Reyal, Y; Vargaftig, J; Lister, TA; Fitzgibbon, J and Bonnet, D (2012)
    Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis.
    Leukemia 26, 1537-1546 PubMed abstract
  • Tamoutounour, S; Henri, S; Lelouard, H; de Bovis, B; de Haar, C; van der Woude, CJ; Woltman, AM; Reyal, Y; Bonnet, D; Sichien, D; Bain, CC; Mowat, AM; Reis e Sousa, C; Poulin, LF; Malissen, B and Guilliams, M (2012)
    CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.
    European Journal of Immunology 42, 3150-3166 PubMed abstract
  • Valent, P; Bonnet, D; De Maria, R; Lapidot, T; Copland, M; Melo, JV; Chomienne, C; Ishikawa, F; Schuringa, JJ; Stassi, G; Huntly, B; Herrmann, H; Soulier, J; Roesch, A; Schuurhuis, GJ; Wöhrer, S; Arock, M; Zuber, J; Cerny-Reiterer, S; Johnsen, HE; Andreeff, M and Eaves, C (2012)
    Cancer stem cell definitions and terminology: the devil is in the details.
    Nature Reviews Cancer 12, 767-775 PubMed abstract
  • Vargaftig, J; Taussig, DC; Griessinger, E; Anjos-Afonso, F; Lister, TA; Cavenagh, J; Oakervee, H; Gribben, J and Bonnet, D (2012)
    Frequency of Leukemic Initiating Cells does not depend on the xenotransplantation model used.
    Leukemia 26, 858-860 PubMed abstract
  • Willems, L; Chapuis, N; Puissant, A; Maciel, TT; Green, AS; Jacque, N; Vignon, C; Park, S; Guichard, S; Herault, O; Fricot, A; Hermine, O; Moura, IC; Auberger, P; Ifrah, N; Dreyfus, F; Bonnet, D; Lacombe, C; Mayeux, P; Bouscary, D and Tamburini, J (2012)
    The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.
    Leukemia 26, 1195-1202
  • Anjos-Afonso, F and Bonnet, D (2011)
    Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells.
    Best Practice & Research. Clinical Haematology 24, 13-24 PubMed abstract
  • Gandillet, A; Park, S; Lassailly, F; Griessinger, E; Vargaftig, J; Filby, A; Lister, TA and Bonnet, D (2011)
    Heterogeneous sensitivity of human Acute Myeloid Leukemia to β-catenin down-modulation.
    Leukemia 25, 770-780 PubMed abstract
  • Kuranda, K; Vargaftig, J; de la Rochere, P; Dosquet, C; Charron, D; Bardin, F; Tonnelle, C; Bonnet, D and Goodhardt, M (2011)
    Age-related changes in human hematopoietic stem/progenitor cells.
    Aging Cell 10, 542-546 PubMed abstract
  • Jaganathan, BG; Tisato, V; Vulliamy, T; Dokal, I; Marsh, J; Dazzi, F and Bonnet, D (2010)
    Effects of MSC co-injection on the reconstitution of aplastic anemia patient following hematopoietic stem cell transplantation.
    Leukemia 24, 1791-1795 PubMed abstract
  • Lassailly, F; Griessinger, E and Bonnet, D (2010)
    "Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking.
    Blood 115, 5347-5354 PubMed abstract
  • Poulin, LF; Salio, M; Griessinger, E; Anjos-Afonso, F; Craciun, L; Chen, J-L; Keller, AM; Joffre, O; Zelenay, S; Nye, E; Le Moine, A; Faure, F; Donckier, V; Sancho, D; Cerundolo, V; Bonnet, D and Reis e Sousa, C (2010)
    Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells.
    Journal of Experimental Medicine 207, 1261-1271 PubMed abstract
  • Taussig, DC and Bonnet, D (2010)
    Cancer Stem Cells.
    In: Molecular Hematology. Edited by Provan, D and Gribben, JG. 3rd edition.
    Oxford, Blackwell Publishing Ltd, 2010. 370-379.
  • Taussig, DC; Vargaftig, J; Miraki-Moud, F; Griessinger, E; Sharrock, K; Luke, T; Lillington, D; Oakervee, H; Cavenagh, J; Agrawal, SG; Lister, TA; Gribben, JG and Bonnet, D (2010)
    Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34- fraction.
    Blood 115, 1976-1984 PubMed abstract
  • Vianello, F; Villanova, F; Tisato, V; Lymperi, S; Ho, KK; Gomes, AR; Marin, D; Bonnet, D; Apperley, J; Lam, EWF and Dazzi, F (2010)
    Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis.
    Haematologica 95, 1081-1089
  • Yeung, J; Esposito, MT; Gandillet, A; Zeisig, BB; Griessinger, E; Bonnet, D and So, CWE (2010)
    β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
    Cancer Cell 18, 606-618 PubMed abstract

[Page last updated 1 Oct 2017]

Dominique Bonnet

Dominique Bonnet

dominique.bonnet@crick.ac.uk
+44 (0)20 379 61198

  • Qualifications and history
  • 1993 PhD, University of Paris VII, France
  • 1993-1997 Postdoctoral Research Fellow, Hospital for Sick Children, Canada
  • 1998 Assistant Professor, Coriell Institute for Medical Research, USA
  • 2001 Adjunct Assistant Professor, University of Pennsylvania, USA
  • 2001 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK