Peter Cherepanov

Chromatin structure and mobile DNA Laboratory

Our laboratory focuses on the structural biology of chromatin function and its interactions with retroviral integration machinery. Using X-ray crystallography as the primary tool, the researchers aim to elucidate three-dimensional structures of the complex machineries involved in regulation of eukaryotic DNA replication, gene expression and chromatin stability. The results will aid in the development of small molecules and virus-based vectors for treatment of cancer.

Selected publications

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P (2017) A supramolecular assembly mediates lentiviral DNA integration. Science 355: 93-5.

Lesbats, P., Engelman, A.N. and Cherepanov, P. (2016) Retroviral DNA Integration.  Chem Rev, 12730-57.

Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov P (2015) Structural basis for retroviral integration into nucleosomes.  Nature 523: 366-9.

Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Oztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, Kewalramani VN, Fassati A, Engelman A, Cherepanov P (2014) Structural basis for nuclear import of splicing factors by human Transportin 3.  Proc Natl Acad Sci USA 111: 2728-33.

Hughes S, Elustondo F, Di Fonzo A, Leroux FG, Wong AC, Snijders AP, Matthews SJ, Cherepanov P (2012) Crystal structure of human Cdc7 kinase in complex with its activator Dbf4.  Nat Struct Mol Biol 19: 1101-7.

Maertens GN, Hare S, Cherepanov P (2010) The mechanism of retroviral integration from X-ray structures of its key intermediates.  Nature 468: 326-9.

Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P (2010) Retroviral intasome assembly and inhibition of DNA strand transfer.  Nature 464: 232-6.

Peter Cherepanov

peter.cherepanov@crick.ac.uk
+44 (0)20 379 61798

  • Qualifications and history
  • 2000 PhD Rega Institute for Medical Research, 2000 Postdoctoral fellow, Rega Institute for Medical Research, Belgium
  • 2003 Postdoctoral fellow, Department of Pathology, Harvard Medical School, Boston, USA
  • 2005 Senior Lecturer, Faculty of Medicine,2009 Reader in Virology, Faculty of Medicine, Imperial College London, UK
  • 2011 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK