Peter Cherepanov: Publications

  • Ballandras-Colas, A; Maskell, DP; Serrao, E; Locke, J; Swuec, P; Jónsson, SR; Kotecha, A; Cook, NJ; Pye, VE; Taylor, IA; Andrésdóttir, V; Engelman, AN; Costa, A and Cherepanov, P (2017)
    A supramolecular assembly mediates lentiviral DNA integration.
    Science 355, 93-95 PubMed abstract
  • Engelman, AN and Cherepanov, P (2017)
    Retroviral intasomes arising.
    Current Opinion in Structural Biology 47, 23-29 PubMed abstract
  • Frigola, J; He, J; Kinkelin, K; Pye, VE; Renault, L; Douglas, ME; Remus, D; Cherepanov, P; Costa, A and Diffley, JFX (2017)
    Cdt1 stabilizes an open MCM ring for helicase loading.
    Nature Communications 8, 15720 PubMed abstract
  • Lesbats, P; Serrao, E; Maskell, DP; Pye, VE; O'Reilly, N; Lindemann, D; Engelman, AN and Cherepanov, P (2017)
    Structural basis for spumavirus GAG tethering to chromatin.
    Proceedings of the National Academy of Sciences of the United States of America 114, 5509-5514 PubMed abstract
  • Zhao, XZ; Smith, SJ; Maskell, DP; Métifiot, M; Pye, VE; Fesen, K; Marchand, C; Pommier, Y; Cherepanov, P; Hughes, SH and Burke, TR, Jr. (2017)
    Structure-guided optimization of HIV integrase strand transfer inhibitors.
    Journal of Medicinal Chemistry 60, 7315-7332 PubMed abstract
  • Ballandras-Colas, A; Brown, M; Cook, NJ; Dewdney, TG; Demeler, B; Cherepanov, P; Lyumkis, D and Engelman, AN (2016)
    Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
    Nature 530, 358-361 PubMed abstract
  • Lesbats, P; Engelman, AN and Cherepanov, P (2016)
    Retroviral DNA integration.
    Chemical Reviews 116, 12730-12757 PubMed abstract
  • Serrao, E; Cherepanov, P and Engelman, AN (2016)
    Amplification, next-generation sequencing, and genomic DNA mapping of retroviral integration sites.
    Journal of Visualized Experiments PubMed abstract
  • Zhao, XZ; Smith, SJ; Maskell, DP; Metifiot, M; Pye, VE; Fesen, K; Marchand, C; Pommier, Y; Cherepanov, P; Hughes, SH and Burke, TR, Jr. (2016)
    HIV-1 integrase strand transfer inhibitors with reduced susceptibility to drug resistant mutant integrases.
    ACS Chemical Biology 11, 1074-1081 PubMed abstract
  • Zurnic, I; Hütter, S; Rzeha, U; Helbig, R; Stanke, N; Reh, J; Müllers, E; Hamann, MV; Kern, T; Gerresheim, GK; Lindel, F; Serrao, E; Lesbats, P; Engelman, AN; Cherepanov, P and Lindemann, D (2016)
    Interactions of prototype foamy virus capsids with host cell polo-like kinases are important for efficient viral DNA integration.
    PLOS Pathogens 12, e1005860 PubMed abstract
  • Maskell, DP; Renault, L; Serrao, E; Lesbats, P; Matadeen, R; Hare, S; Lindemann, D; Engelman, AN; Costa, A and Cherepanov, P (2015)
    Structural basis for retroviral integration into nucleosomes.
    Nature 523, 366-369 PubMed abstract
  • Serrao, E; Ballandras-Colas, A; Cherepanov, P; Maertens, GN and Engelman, AN (2015)
    Key determinants of target DNA recognition by retroviral intasomes.
    Retrovirology 12, 39 PubMed abstract
  • Engelman, A and Cherepanov, P (2014)
    Retroviral integrase structure and DNA recombination mechanism.
    Microbiology Spectrum 2, 1-22 PubMed abstract
  • Maertens, GN; Cook, NJ; Wang, W; Hare, S; Gupta, SS; Öztop, I; Lee, K; Pye, VE; Cosnefroy, O; Snijders, AP; KewalRamani, VN; Fassati, A; Engelman, A and Cherepanov, P (2014)
    Structural basis for nuclear import of splicing factors by human Transportin 3.
    Proceedings of the National Academy of Sciences of the United States of America 111, 2728-2733 PubMed abstract
  • Serrao, E; Krishnan, L; Shun, M-C; Li, X; Cherepanov, P; Engelman, A and Maertens, GN (2014)
    Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.
    Nucleic Acids Research 42, 5164-5176 PubMed abstract
  • Wang, H; Shun, M-C; Li, X; Di Nunzio, F; Hare, S; Cherepanov, P and Engelman, A (2014)
    Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses.
    Molecular Therapy. Methods & Clinical Development 1, 2 PubMed abstract
  • Gupta, SS; Maetzig, T; Maertens, GN; Sharif, A; Rothe, M; Weidner-Glunde, M; Galla, M; Schambach, A; Cherepanov, P and Schulz, TF (2013)
    Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.
    Journal of Virology 87, 12721-12736 PubMed abstract
  • Métifiot, M; Maddali, K; Johnson, BC; Hare, S; Smith, SJ; Zhao, XZ; Marchand, C; Burke, TR, Jr.; Hughes, SH; Cherepanov, P and Pommier, Y (2013)
    Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
    ACS Chemical Biology 8, 209-217 PubMed abstract
  • Engelman, A and Cherepanov, P (2012)
    The structural biology of HIV-1: mechanistic and therapeutic insights.
    Nature Reviews Microbiology 10, 279-290 PubMed abstract
  • Gupta, K; Curtis, JE; Krueger, S; Hwang, Y; Cherepanov, P; Bushman, FD and Van Duyne, GD (2012)
    Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.
    Structure 20, 1918-1928 PubMed abstract
  • Hare, S; Maertens, GN and Cherepanov, P (2012)
    3'-processing and strand transfer catalysed by retroviral integrase in crystallo.
    EMBO Journal 31, 3020-3028 PubMed abstract
  • Hughes, S; Elustondo, F; Di Fonzo, A; Leroux, FG; Wong, AC; Snijders, AP; Matthews, SJ and Cherepanov, P (2012)
    Crystal structure of human CDC7 kinase in complex with its activator DBF4.
    Nature Structural & Molecular Biology 19, 1101-1107 PubMed abstract
  • Lekomtsev, S; Su, K-C; Pye, VE; Blight, K; Sundaramoorthy, S; Takaki, T; Collinson, LM; Cherepanov, P; Divecha, N and Petronczki, M (2012)
    Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.
    Nature 492, 276-279 PubMed abstract
  • Wang, H; Jurado, KA; Wu, X; Shun, M-C; Li, X; Ferris, AL; Smith, SJ; Patel, PA; Fuchs, JR; Cherepanov, P; Kvaratskhelia, M; Hughes, SH and Engelman, A (2012)
    HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
    Nucleic Acids Research 40, 11518-11530 PubMed abstract
  • Cherepanov, P; Maertens, GN and Hare, S (2011)
    Structural insights into the retroviral DNA integration apparatus.
    Current Opinion in Structural Biology 21, 249-256 PubMed abstract
  • Hare, S; Engelman, A and Cherepanov, P (2011)
    Structural aspects of the lentiviral integrase - LEDGF interaction.
    In: HIV-1 integrase: mechanism and inhibitor design. Edited by Neamati, N and Wang, B.
    John Wiley & Sons, 2011. 131-140. (Wiley Series in Drug Discovery and Development).
  • Hare, S; Smith, SJ; Métifiot, M; Jaxa-Chamiec, A; Pommier, Y; Hughes, SH and Cherepanov, P (2011)
    Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).
    Molecular Pharmacology 80, 565-572 PubMed abstract
  • Li, X; Krishnan, L; Cherepanov, P and Engelman, A (2011)
    Structural biology of retroviral DNA integration.
    Virology 411, 194-205 PubMed abstract
  • Cherepanov, P (2010)
    Integrase illuminated.
    EMBO Reports 11, 328 PubMed abstract
  • Hare, S; Gupta, SS; Valkov, E; Engelman, A and Cherepanov, P (2010)
    Retroviral intasome assembly and inhibition of DNA strand transfer.
    Nature 464, 232-236 PubMed abstract
  • Hare, S; Vos, AM; Clayton, RF; Thuring, JW; Cummings, MD and Cherepanov, P (2010)
    Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
    Proceedings of the National Academy of Sciences of the United States of America 107, 20057-20062 PubMed abstract
  • Hughes, S; Jenkins, V; Dar, MJ; Engelman, A and Cherepanov, P (2010)
    Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.
    Journal of Biological Chemistry 285, 541-554 PubMed abstract
  • Krishnan, L; Li, X; Naraharisetty, HL; Hare, S; Cherepanov, P and Engelman, A (2010)
    Structure-based modeling of the functional HIV-1 intasome and its inhibition.
    Proceedings of the National Academy of Sciences of the United States of America 107, 15910-15915 PubMed abstract
  • Maertens, GN; Hare, S and Cherepanov, P (2010)
    The mechanism of retroviral integration from X-ray structures of its key intermediates.
    Nature 468, 326-329 PubMed abstract

[Page last updated 1 Nov 2017]

Peter Cherepanov

peter.cherepanov@crick.ac.uk
+44 (0)20 379 61798

  • Qualifications and history
  • 2000 PhD Rega Institute for Medical Research, 2000 Postdoctoral fellow, Rega Institute for Medical Research, Belgium
  • 2003 Postdoctoral fellow, Department of Pathology, Harvard Medical School, Boston, USA
  • 2005 Senior Lecturer, Faculty of Medicine,2009 Reader in Virology, Faculty of Medicine, Imperial College London, UK
  • 2011 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK