Maximiliano Gutierrez: Publications

  • Gutierrez, MG and Carlton, JG (2018)
    ESCRTs offer repair service.
    Science 360, 33-34 PubMed abstract
  • Härtlova, A; Herbst, S; Peltier, J; Rodgers, A; Bilkei-Gorzo, O; Fearns, A; Dill, BD; Lee, H; Flynn, R; Cowley, SA; Davies, P; Lewis, PA; Ganley, IG; Martinez, J; Alessi, DR; Reith, AD; Trost, M and Gutierrez, MG (2018)
    LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
    EMBO Journal 2018, e98694 PubMed abstract
  • Lerner, TR; Queval, CJ; Fearns, A; Repnik, U; Griffiths, G and Gutierrez, MG (2018)
    Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells.
    BMC Biology 16, 1 PubMed abstract
  • Lerner, TR; Borel, S; Greenwood, DJ; Repnik, U; Russell, MRG; Herbst, S; Jones, ML; Collinson, LM; Griffiths, G and Gutierrez, MG (2017)
    Mycobacterium tuberculosis replicates within necrotic human macrophages.
    Journal of Cell Biology 216, 583-594 PubMed abstract
  • Pires, D; Bernard, EM; Pombo, JP; Carmo, N; Fialho, C; Gutierrez, MG; Bettencourt, P and Anes, E (2017)
    Mycobacterium tuberculosis modulates miR-106b-5p to control cathepsin S expression resulting in higher pathogen survival and poor T-cell activation.
    Frontiers in Immunology 8, 1819 PubMed abstract
  • Prashar, A; Schnettger, L; Bernard, EM and Gutierrez, MG (2017)
    Rab GTPases in immunity and inflammation.
    Frontiers in Cellular and Infection Microbiology 7, 435 PubMed abstract
  • Russell, MRG; Lerner, TR; Burden, JJ; Nkwe, DO; Pelchen-Matthews, A; Domart, M-C; Durgan, J; Weston, A; Jones, ML; Peddie, CJ; Carzaniga, R; Florey, O; Marsh, M; Gutierrez, MG and Collinson, LM (2017)
    3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy.
    Journal of Cell Science 130, 278-291 PubMed abstract
  • Schnettger, L and Gutierrez, MG (2017)
    Quantitative spatiotemporal analysis of phagosome maturation in live cells.
    Methods in Molecular Biology 1519, 169-184 PubMed abstract
  • Schnettger, L; Rodgers, A; Repnik, U; Lai, RP; Pei, G; Verdoes, M; Wilkinson, RJ; Young, DB and Gutierrez, MG (2017)
    A Rab20-dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity.
    Cell Host & Microbe 21, 619-628.e615 PubMed abstract
  • Vázquez, CL; Bianco, MV; Blanco, FC; Forrellad, M; Gutierrez, MG and Bigi, F (2017)
    Mycobacterium bovis requires P27 (LprG) to arrest phagosome maturation and replicate within bovine macrophages.
    Infection and Immunity 85, e00720-00716 PubMed abstract
  • Warnatsch, A; Tsourouktsoglou, T-D; Branzk, N; Wang, Q; Reincke, S; Herbst, S; Gutierrez, M and Papayannopoulos, V (2017)
    Reactive oxygen species localization programs inflammation to clear microbes of different size.
    Immunity 46, 421-432 PubMed abstract
  • Diedrich, CR; O'Hern, J; Gutierrez, MG; Allie, N; Papier, P; Meintjes, G; Coussens, AK; Wainwright, H and Wilkinson, RJ (2016)
    Relationship between HIV coinfection, interleukin 10 production, and Mycobacterium tuberculosis in human lymph node granulomas.
    Journal of Infectious Diseases 214, 1309-1318 PubMed abstract
  • Klionsky, DJ; Abdelmohsen, K; ...; Gutierrez, MG; ...; Swanton, C; ... and Tooze, SA (2016)
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Autophagy 12, 1-222 PubMed abstract
  • Larrouy-Maumus, G; Marino, LB; Madduri, AVR; Ragan, TJ; Hunt, DM; Bassano, L; Gutierrez, MG; Moody, DB; Pavan, FR and de Carvalho, LPS (2016)
    Cell-envelope remodeling as a determinant of phenotypic antibacterial tolerance in Mycobacterium tuberculosis.
    ACS Infectious Diseases 2, 352-360 PubMed abstract
  • Lerner, TR; de Souza Carvalho-Wodarz, C; Repnik, U; Russell, MRG; Borel, S; Diedrich, CR; Rohde, M; Wainwright, H; Collinson, LM; Wilkinson, RJ; Griffiths, G and Gutierrez, MG (2016)
    Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis.
    Journal of Clinical Investigation 126, 1093-1108 PubMed abstract
  • Vázquez, CL; Rodgers, A; Herbst, S; Coade, S; Gronow, A; Guzman, CA; Wilson, MS; Kanzaki, M; Nykjaer, A and Gutierrez, MG (2016)
    The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.
    Scientific Reports 6, 29332 PubMed abstract
  • Lerner, TR; Borel, S and Gutierrez, MG (2015)
    The innate immune response in human tuberculosis.
    Cellular Microbiology 17, 1277-1285 PubMed abstract
  • Pei, G; Schnettger, L; Bronietzki, M; Repnik, U; Griffiths, G and Gutierrez, MG (2015)
    Interferon-γ-inducible Rab20 regulates endosomal morphology and EGFR degradation in macrophages.
    Molecular Biology of the Cell 26, 3061-3070 PubMed abstract
  • Branzk, N; Lubojemska, A; Hardison, SE; Wang, Q; Gutierrez, MG; Brown, GD and Papayannopoulos, V (2014)
    Microbial size regulates neutrophil responses for efficient immune defence and minimal host damage.
    Immunology 143, 92, Abstract 179
  • Branzk, N; Lubojemska, A; Hardison, SE; Wang, Q; Gutierrez, MG; Brown, GD and Papayannopoulos, V (2014)
    Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens.
    Nature Immunology 15, 1017-1025 PubMed abstract
  • Bronietzki, M; Kasmapour, B and Gutierrez, MG (2014)
    Study of phagolysosome biogenesis in live macrophages.
    Journal of Visualized Experiments 85, e51201 PubMed abstract
  • Gutierrez, MG (2014)
    Intracellular trafficking of phagosomes: lessons from mycobacteria.
    Biocell 38, 53, Abstract CB-S02
  • Pei, G; Repnik, U; Griffiths, G and Gutierrez, MG (2014)
    Identification of an immune regulated phagosomal Rab cascade in macrophages.
    Journal of Cell Science 127, 2071-2082 PubMed abstract
  • Shevchuk, O; Pägelow, D; Rasch, J; Döhrmann, S; Günther, G; Hoppe, J; Ünal, CM; Bronietzki, M; Gutierrez, MG and Steinert, M (2014)
    Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection.
    International Journal of Medical Microbiology 304, 1169-1181 PubMed abstract
  • Vázquez, CL; Lerner, TR; Kasmapour, B; Pei, G; Gronow, A; Bianco, MV; Blanco, FC; Bleck, CKE; Geffers, R; Bigi, F; Abraham, W-R and Gutierrez, MG (2014)
    Experimental selection of long-term intracellular mycobacteria.
    Cellular Microbiology 16, 1425-1440 PubMed abstract
  • Estrela, AB; Rohde, M; Gutierrez, MG; Molinari, G and Abraham, W-R (2013)
    Human β-defensin-2 induces extracellular accumulation of adenosine in Escherichia coli.
    Antimicrobial Agents and Chemotherapy 57, 4387-4393 PubMed abstract
  • Forrellad, MA; Bianco, MV; Blanco, FC; Nuñez, J; Klepp, LI; Vazquez, CL; de la Santangelo, MP; Rocha, RV; Soria, M; Golby, P; Gutierrez, MG and Bigi, F (2013)
    Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis.
    BMC Microbiology 13, 200 PubMed abstract
  • Gutierrez, MG (2013)
    Functional role(s) of phagosomal Rab GTPases.
    Small GTPases 4, 148-158 PubMed abstract
  • Kasmapour, B; Cai, L and Gutierrez, MG (2013)
    Spatial distribution of phagolysosomes is independent of the regulation of lysosome position by Rab34.
    International Journal of Biochemistry and Cell Biology 45, 2057-2065 PubMed abstract
  • Ziętara, N; Łyszkiewicz, M; Puchałka, J; Pei, G; Gutierrez, MG; Lienenklaus, S; Hobeika, E; Reth, M; Martins dos Santos, VAP; Krueger, A and Weiss, S (2013)
    Immunoglobulins drive terminal maturation of splenic dendritic cells.
    Proceedings of the National Academy of Sciences of the United States of America 110, 2282-2287 PubMed abstract
  • Kasmapour, B; Gronow, A; Bleck, CKE; Hong, W and Gutierrez, MG (2012)
    Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34.
    Proceedings of the National Academy of Sciences of the United States of America 109, 20485-20490 PubMed abstract
  • Nörder, M; Gutierrez, MG; Zicari, S; Cervi, E; Caruso, A and Guzmán, CA (2012)
    Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation.
    FASEB Journal 26, 2835-2846 PubMed abstract
  • Pei, G; Bronietzki, M and Gutierrez, MG (2012)
    Immune regulation of Rab proteins expression and intracellular transport.
    Journal of Leukocyte Biology 92, 41-50 PubMed abstract
  • Schindler, D; Gutierrez, MG; Beineke, A; Rauter, Y; Rohde, M; Foster, S; Goldmann, O and Medina, E (2012)
    Dendritic cells are central coordinators of the host immune response to Staphylococcus aureus bloodstream infection.
    American Journal of Pathology 181, 1327-1337 PubMed abstract
  • de Souza Carvalho, C; Kasmapour, B; Gronow, A; Rohde, M; Rabinovitch, M and Gutierrez, MG (2011)
    Internalization, phagolysosomal biogenesis and killing of mycobacteria in enucleated epithelial cells.
    Cellular Microbiology 13, 1234-1249 PubMed abstract
  • Bleck, CKE; Merz, A; Gutierrez, MG; Walther, P; Dubochet, J; Zuber, B and Griffiths, G (2010)
    Comparison of different methods for thin section EM analysis of Mycobacterium smegmatis.
    Journal of Microscopy 237, 23-38 PubMed abstract
  • Gutierrez, MG (2010)
    Salmonella vacuole maturation: PIKfyve leads the way.
    EMBO Journal 29, 1316-1317 PubMed abstract
  • Wähe, A; Kasmapour, B; Schmaderer, C; Liebl, D; Sandhoff, K; Nykjaer, A; Griffiths, G and Gutierrez, MG (2010)
    Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.
    Journal of Cell Science 123, 2502-2511 PubMed abstract

[Page last updated 1 Jun 2018]

Maximiliano Gutierrez
+44 (0)20 379 61460

  • Qualifications and history
  • 2002 Biochemistry Degree, Universidad Nacional de San Luis, Argentina
  • 2003 Research Visitor, University of New Mexico, USA
  • 2004 Research Visitor, European Molecular Biology Laboratories (EMBL), Germany
  • 2005 PhD in Biochemistry, Universidad Nacional de Cuyo, Argentina
  • 2006 Post-Doctoral Fellow, European Molecular Biology Laboratories (EMBL), Germany
  • 2009 Junior Group Leader, Helmholtz Centre for Infection Research (HZI), Germany
  • 2012 Programme Leader Track, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK