George Kassiotis: Publications

  • Attig, J; Young, GR; Stoye, JP and Kassiotis, G (2017)
    Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes.
    Frontiers in Microbiology 8, 2489 PubMed abstract
  • Eksmond, U; Jenkins, B; Merkenschlager, J; Mothes, W; Stoye, JP and Kassiotis, G (2017)
    Mutation of the putative immunosuppressive domain of the retroviral envelope glycoprotein compromises infectivity.
    Journal of Virology 91, e01152-01117 PubMed abstract
  • Fontaine, M; Vogel, I; Van Eycke, Y-R; Galuppo, A; Ajouaou, Y; Decaestecker, C; Kassiotis, G; Moser, M and Leo, O (2017)
    Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells.
    EMBO Journal e96881 PubMed abstract
  • Kassiotis, G and Stoye, JP (2017)
    Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer.
    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 372, 20160277 PubMed abstract
  • Donnarumma, T; Young, GR; Merkenschlager, J; Eksmond, U; Bongard, N; Nutt, SL; Boyer, C; Dittmer, U; Le-Trilling, VTK; Trilling, M; Bayer, W and Kassiotis, G (2016)
    Opposing development of cytotoxic and follicular helper CD4 T cells controlled by the TCF-1-Bcl6 nexus.
    Cell Reports 17, 1571-1583 PubMed abstract
  • Jenkins, B; Eksmond, U; Young, G and Kassiotis, G (2016)
    Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein.
    Wellcome Open Research 1, 22 PubMed abstract
  • Kassiotis, G and Stoye, JP (2016)
    Immune responses to endogenous retroelements: taking the bad with the good.
    Nature Reviews Immunology 16, 207-219 PubMed abstract
  • Li, SX; Barrett, BS; Guo, K; Kassiotis, G; Hasenkrug, KJ; Dittmer, U; Gibbert, K and Santiago, ML (2016)
    Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
    Scientific Reports 6, 20425 PubMed abstract
  • Mavrommatis, B; Baudino, L; Levy, P; Merkenschlager, J; Eksmond, U; Donnarumma, T; Young, G; Stoye, J and Kassiotis, G (2016)
    Dichotomy between T cell and B cell tolerance to neonatal retroviral infection permits T cell therapy.
    Journal of Immunology 197, 3628-3638 PubMed abstract
  • Merkenschlager, J; Ploquin, MJ; Eksmond, U; Andargachew, R; Thorborn, G; Filby, A; Pepper, M; Evavold, B and Kassiotis, G (2016)
    Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.
    Nature Communications 7, 10281 PubMed abstract
  • Merkenschlager, J and Kassiotis, G (2015)
    Narrowing the gap: preserving repertoire diversity despite clonal selection during the CD4 T cell response.
    Frontiers in Immunology 6, 413 PubMed abstract
  • Kassiotis, G (2014)
    Endogenous retroviruses and the development of cancer.
    Journal of Immunology 192, 1343-1349 PubMed abstract
  • Li, SX; Barrett, BS; Heilman, KJ; Messer, RJ; Liberatore, RA; Bieniasz, PD; Kassiotis, G; Hasenkrug, KJ and Santiago, ML (2014)
    Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.
    Journal of Immunology 193, 306-316 PubMed abstract
  • Ng, DHL; Skehel, JJ; Kassiotis, G and Langhorne, J (2014)
    Recovery of an antiviral antibody response following attrition caused by unrelated infection.
    PLOS Pathogens 10, e1003843 PubMed abstract
  • Thorborn, G; Ploquin, MJ; Eksmond, U; Pike, R; Bayer, W; Dittmer, U; Hasenkrug, KJ; Pepper, M and Kassiotis, G (2014)
    Clonotypic composition of the CD4+ T cell response to a vectored retroviral antigen is determined by its speed.
    Journal of Immunology 193, 1567-1577 PubMed abstract
  • Thorborn, G; Young, GR and Kassiotis, G (2014)
    Effective T helper cell responses against retroviruses: are all clonotypes equal?
    Journal of Leukocyte Biology 96, 27-37 PubMed abstract
  • Young, GR; Mavrommatis, B and Kassiotis, G (2014)
    Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes.
    Retrovirology 11, 59 PubMed abstract
  • Mavrommatis, B; Young, GR and Kassiotis, G (2013)
    Counterpoise between the microbiome, host immune activation and pathology.
    Current Opinion in Immunology 25, 456-462 PubMed abstract
  • Myers, L; Joedicke, JJ; Carmody, AB; Messer, RJ; Kassiotis, G; Dudley, JP; Dittmer, U and Hasenkrug, KJ (2013)
    IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection.
    Journal of Immunology 190, 5485-5495 PubMed abstract
  • Young, GR; Stoye, JP and Kassiotis, G (2013)
    Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis.
    Bioessays 35, 794-803 PubMed abstract
  • Duley, AK; Ploquin, MJ-Y; Eksmond, U; Ammann, CG; Messer, RJ; Myers, L; Hasenkrug, KJ and Kassiotis, G (2012)
    Negative impact of IFN-γ on early host immune responses to retroviral infection.
    Journal of Immunology 189, 2521-2529 PubMed abstract
  • Young, GR; Eksmond, U; Salcedo, R; Alexopoulou, L; Stoye, JP and Kassiotis, G (2012)
    Resurrection of endogenous retroviruses in antibody-deficient mice.
    Nature 491, 774-778 PubMed abstract
  • Young, GR; Kassiotis, G and Stoye, JP (2012)
    Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice.
    Retrovirology 9, 23 PubMed abstract
  • Young, GR; Ploquin, MJ; Eksmond, U; Wadwa, M; Stoye, JP and Kassiotis, G (2012)
    Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.
    PLOS Pathogens 8, e1002709 PubMed abstract
  • Nair, S; Bayer, W; Ploquin, MJ-Y; Kassiotis, G; Hasenkrug, KJ and Dittmer, U (2011)
    Distinct roles of CD4+ T cell subpopulations in retroviral immunity: Lessons from the Friend Virus mouse model.
    Retrovirology 8, 76 PubMed abstract
  • Ploquin, MJ-Y; Eksmond, U and Kassiotis, G (2011)
    B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection.
    Journal of Immunology 187, 3321-3330
  • Antunes, I and Kassiotis, G (2010)
    Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice.
    Journal of Virology 84, 12564-12575 PubMed abstract
  • Nair, SR; Zelinskyy, G; Schimmer, S; Gerlach, N; Kassiotis, G and Dittmer, U (2010)
    Mechanisms of control of acute Friend virus infection by CD4+ helper T cells and their functional impairment by regulatory T cells.
    Journal of General Virology 91, 440-451 PubMed abstract

[Page last updated 1 Jun 2018]

George Kassiotis
+44 (0)20 379 61483

  • Qualifications and history
  • 2000 PhD in Immunology, Hellenic Pasteur Institute, Athens, Greece
  • 2000 Post-doctoral Fellow, Medical Research Council National Institute for Medical Research (MRC NIMR), London, UK
  • 2005 Programme Leader Track, MRC NIMR, London, UK
  • 2011 Programme Leader, MRC NIMR, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK